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Authors: Amos, Christopher I | Wang, Li-E | Schacherer, Christopher W | Taylor, John C | Whittaker, Linda | Kukalizch, Kairen | Leake, Susan | Karpavicius, Birute | Haynes, Sue | Mack, Tricia | Chan, May | Taylor, Yvonne | Davies, John | Gardner, Julie M | King, Paul | Gruis, Nelleke A | van Nieuwpoort, Frans A | Out, Coby | van der Drift, Clasine | Bergman, Wilma | Kukutsch, Nicole | Bouwes Bavinck, Jan Nico | Bakker, Bert | van der Stoep, Nienke | Wang, Yuling | ter Huurne, Jeanet | van der Rhee, Han | Bekkenk, Marcel | Snels, Dyon | van Praag, Marinus | Brochez, Lieve | Gerritsen, Rianne | Crijns, Marianne | Vasen, Hans | Olsson, Håkan | Bishop, D. Tim | Ingvar, Christian | Jönsson, Göron | Borg, Åke | Måsbäck, Anna | Lundgren, Lotta | Baeckenhorn, Katja | Nielsen, Kari | Schmidt Casslén, Anita | Helsing, Per | Andresen, Per Arne | Barrett, Jennifer H | Rootwelt, Helge | Akslen, Lars | Molven, Anders | Avril, Marie-Françoise | Bressac-de Paillerets, Brigitte | Chaudru, Valérie | Chateigner, Nicolas | Corda, Eve | Jeannin, Patricia | Lesueur, Fabienne | MacGregor, Stuart | de Lichy, Mahaut | Maubec, Eve | Mohamdi, Hamida | Demenais, Florence | Andry-Benzaquen, Pascale | Bachollet, Bertrand | Bérard, Frédéric | Berthet, Pascaline | Boitier, Françoise | Bonadona, Valére | Hayward, Nicholas K | Bonafé, Jean-Louis | Bonnetblanc, Jean-Marie | Cambazard, Frédéric | Caron, Olivier | Caux, Frédéric | Chevrant-Breton, Jacqueline | Chompret, Angès | Dalle, Stéphane | Demange, Liliane | Dereure, Olivier | Martin, Nicholas G | Doré, Martin-Xavier | Doutre, Marie-Sylvie | Dugast, Catherine | Faivre, Laurence | Grange, Florent | Humbert, Philippe | Joly, Pascal | Kerob, Delphine | Lasset, Christine | Leccia, Marie Thérèse | Duffy, David L | Lenoir, Gilbert | Leroux, Dominique | Levang, Julien | Lipsker, Dan | Mansard, Sandrine | Martin, Ludovic | Martin-Denavit, Tanguy | Mateus, Christine | Michel, Jean- Loïc | Morel, Patrice | Mann, Graham J | Olivier-Faivre, Laurence | Perrot, Jean-Luc | Robert, Caroline | Ronger-Savle, Sandra | Sassolas, Bruno | Souteyrand, Pierre | Stoppa-Lyonnet, Dominique | Thomas, Luc | Vabres, Pierre | Wierzbicka, Eva | Lee, Jeffrey E | Cust, Anne | Elder, David | Kanetsky, Peter | Knorr, Jillian | Ming, Michael | Mitra, Nandita | Ruffin, Althea | Van Belle, Patricia | Dębniak, Tadeusz | Lubiński, Jan | Mirecka, Aneta | Hopper, John | Ertmański, Sławomir | Novakovic, Srdjan | Hocevar, Marko | Peric, Barbara | Cerkovnik, Petra | Höiom, Veronica | Hansson, Johan | Holland, Elizabeth A | Azizi, Esther | Galore-Haskel, Gilli | Brown, Kevin M | Friedman, Eitan | Baron-Epel, Orna | Scope, Alon | Pavlotsky, Felix | Yakobson, Emanuel | Cohen-Manheim, Irit | Laitman, Yael | Milgrom, Roni | Shimoni, Iris | Kozlovaa, Evgeniya | Grimm, Elizabeth A | Xu, Yaji | Han, Younghun | Jing, Kaiyan | McHugh, Caitlin | Laurie, Cathy C | Doheny, Kim F | Gershenwald, Jeffrey E | Pugh, Elizabeth W | Seldin, Michael F | Han, Jiali | Wei, Qingyi | Aitken, Joanne F | Armstrong, Bruce K | Giles, Graham G | Kefford, Richard F | Chen, Wei V | Jenkins, Mark A | Schmid, Helen | Aguilera, Paula | Badenas, Celia | Carrera, Cristina | Cuellar, Francisco | Gabriel, Daniel | Martinez, Estefania | Gonzalez, Melinda | Fang, Shenying | Iglesias, Pablo | Malvehy, Josep | Marti-Laborda, Rosa | Mila, Montse | Ogbah, Zighe | Puig Butille, Joan-Anton | Puig, Susana | Alós, Llúcia | Arance, Ana | Arguís, Pedro | Kosoy, Roman | Campo, Antonio | Castel, Teresa | Conill, Carlos | Palou, Jose | Rull, Ramon | Sánchez, Marcelo | Vidal-Sicart, Sergi | Vilalta, Antonio | Vilella, Ramon | Montgomery, Grant W | Zhang, Mingfeng | Whiteman, David C | Webb, Penny | Green, Adele | Parsons, Peter | Purdie, David | Landi, Maria Teresa | Calista, Donato | Landi, Giorgio | Minghetti, Paola | Arcangeli, Fabio | Qureshi, Abrar A | Bertazzi, Pier Alberto | Bianchi-Scarra, Giovanna | Ghiorzo, Paola | Pastorino, Lorenza | Bruno, William | Battistuzzi, Linda | Gargiulo, Sara | Nasti, Sabina | Gliori, Sara | Origone, Paola | Vattathil, Selina | Andreotti, Virginia | Queirolo, Paola | Mackie, Rona | Lang, Julie | Newton Bishop, Julia A | Affleck, Paul | Harrison, Jane | Iles, Mark M | Randerson-Moor, Juliette | Harland, Mark
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/305992
Description: We performed a multistage genome-wide association study of melanoma. In a discovery cohort of 1804 melanoma cases and 1026 controls, we identified loci at chromosomes 15q13.1 (HERC2/OCA2 region) and 1 ... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/296087
Description: We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control indiv ... More
Reviewed: Reviewed
Date: 2011
Subject Keyword: 110300 Clinical Sciences
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294866
Description: Background CDKN2A mutations confer a substantial risk of cutaneous melanoma; however, the magnitude of risk is uncertain. Methods The study estimated the hazard ratio (HR) and the average age specific ... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294838
Description: Purpose: To assess the frequency and type of oncogenic BRAF mutations in metastatic melanoma and correlate BRAF status with clinicopathologic features and outcome. Patients and Methods: Consecutive BR ... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294845
Description: 4 page(s)
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294805
Description: Sunbed use is associated with increased risk of melanoma. Younger people might be more susceptible to the carcinogenic effects of ultraviolet radiation. We investigated the association between sunbed ... More
Reviewed: Reviewed
Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295056
Description: Induction of senescence permanently restricts cellular proliferation after oncogenic stimulation thereby acting as a potent barrier to tumor development. The relevant effector proteins may therefore b ... More
Reviewed: Reviewed
Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295044
Description: Inherited mutations affecting the INK4a/ARF locus (CDKN2A) are associated with melanoma susceptibility in 40% of multiple case melanoma families. Over 60 different germline INK4a/ARF mutations have be ... More
Reviewed: Reviewed
Date: 2009
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295864
Description: We report a genome-wide association study of melanoma conducted by the GenoMEL consortium based on 317K tagging SNPs for 1,650 selected cases and 4,336 controls, with replication in an additional two ... More
Reviewed: Reviewed
Date: 2009
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295232
Description: Discovering and understanding genetic risk factors for melanoma and their interactions with phenotype, sun exposure, and other risk factors could lead to new strategies for melanoma control. This pape ... More
Reviewed: Reviewed
Date: 2009
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295085
Description: Background: CDKN2A/p16INK4a is frequently altered in human cancers and it is the most important melanoma susceptibility gene identified to date. p16INK4a inhibits pRb phosphorylation and induces cell ... More
Reviewed: Reviewed
Date: 2008
Subject Keyword: 110300 Clinical Sciences
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295588
Description: Metastatic cutaneous melanoma is highly resistant to cytotoxic drugs, and this contributes to poor prognosis. In vivo studies on the chemosensitivity of metastatic melanoma are rare and hampered by po ... More
Reviewed: Reviewed