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Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1058198
Description: Background: Acquired resistance to BRAF inhibitors (BRAFi) is a near-universal phenomenon caused by numerous genetic and non-genetic alterations. In this study, we evaluated the spectrum, onset, patte ... More
Reviewed: Reviewed
Date: 2014
Subject Keyword: anoikis | B-RAF | MAPK | Mcl-1 | STAT3
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/304454
Description: Approximately 50% of melanomas depend on mutant B-RAF for proliferation, metastasis and survival. The inhibition of oncogenic B-RAF with highly targeted compounds has produced remarkable albeit short- ... More
Reviewed: Reviewed
Date: 2014
Subject Keyword: MAPK | c-Kit | PI3K
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/341265
Description: Mutations activating the receptor tyrosine kinase c-Kit occur commonly in melanomas arising on mucosal membranes and acral skin. Clinical studies have demonstrated that selective inhibition of c-Kit i ... More
Full Text: Full Text
Reviewed: Reviewed
Date: 2014
Subject Keyword: c-Kit | MAPK | melanocytes | melanoma | PI3K | stem cell factor
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/340749
Description: Stimulation of the c-Kit receptor tyrosine kinase has a critical role in the development and migration of melanocytes, and oncogenic c-Kit mutants contribute to the progression of some melanomas. c-Ki ... More
Reviewed: Reviewed
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