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Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/357615
Description: Seven-membered N-heterocycles are flexible ring structures, and their conformational control is important to their bioactivity. Our prior work shows that stereoselective monofluorination, if installed ... More
Reviewed: Reviewed
Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1055055
Description: The structure of the title compound, C₁₅H₁₆F₆N₄O₃, was determined using synchrotron radiation on an extremely small crystal (0.015 × 0.01 × 0.01 mm). Although the diffraction was weak, leading to high ... More
Full Text: Full Text
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/309130
Description: Substituted azepanes have flexible ring structures and this conformational diversity is important for their bioactivity. We have shown that a single fluorine atom, when installed diastereoselectively ... More
Reviewed: Reviewed
Date: 2013
Subject Keyword: 030500 Organic Chemistry
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/277835
Description: Substituted azepanes are common bioactive epitopes with flexible ring structures. The conformational effects of monofluorination in model azepane rings were investigated by H-1 NMR spectroscopy and co ... More
Reviewed: Reviewed
Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/270028
Description: Fluorination of bioactive compounds is an important step in drug discovery and development. Fluorination has been extensively studied in acyclic systems, carbocycles, and fused heterocycles. However, ... More
Reviewed: Reviewed
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