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Date: 2017
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1250822
Description: Acquiring a divergent response from homologous protein domains is essential for selective ligand-protein interactions. Stereospecific fluorination of (−)-balanol, an ATP mimic, uncovers a new source o ... More
Reviewed: Reviewed
Date: 2016
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/1251099
Description: 2 page(s)
Authors: Kenny, Ryan | Liu, Fei
Date: 2016
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1257549
Description: Cooperativity is essential to proficient catalysis, and designing biomimetic, cooperative catalysis is a major avenue to finding new and efficient chemical reactions with practical applications. One c ... More
Reviewed: Reviewed
Date: 2016
Language: eng
Resource Type: conference poster
Identifier: http://hdl.handle.net/1959.14/1249191
Description: 1 page(s)
Date: 2016
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1192167
Description: Claudins are the major transmembrane protein components of tight junctions in human endothelia and epithelia. Tissue-specific expression of claudin members suggests that this protein family is not onl ... More
Reviewed: Reviewed
Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/357615
Description: Seven-membered N-heterocycles are flexible ring structures, and their conformational control is important to their bioactivity. Our prior work shows that stereoselective monofluorination, if installed ... More
Reviewed: Reviewed
Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1055055
Description: The structure of the title compound, C₁₅H₁₆F₆N₄O₃, was determined using synchrotron radiation on an extremely small crystal (0.015 × 0.01 × 0.01 mm). Although the diffraction was weak, leading to high ... More
Full Text: Full Text
Reviewed: Reviewed
Date: 2015
Language: eng
Resource Type: conference poster
Identifier: http://hdl.handle.net/1959.14/1051498
Description: 1 page(s)
Authors: Kenny, Ryan | Liu, Fei
Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1051556
Description: In this microreview, trifunctional organocatalysts, defined as catalysts with three distinct mechanistic functionalities, are surveyed in order to understand not just catalytic activation but also cat ... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/309130
Description: Substituted azepanes have flexible ring structures and this conformational diversity is important for their bioactivity. We have shown that a single fluorine atom, when installed diastereoselectively ... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/319682
Description: Genetic variations of leucine-rich repeat kinase 2 (LRRK2) are the major cause of dominantly inherited Parkinson disease (PD). LRRK2 protein contains seven predicted domains: a tandem Ras-like GTPase ... More
Reviewed: Reviewed
Date: 2013
Subject Keyword: 030500 Organic Chemistry
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/277835
Description: Substituted azepanes are common bioactive epitopes with flexible ring structures. The conformational effects of monofluorination in model azepane rings were investigated by H-1 NMR spectroscopy and co ... More
Reviewed: Reviewed
Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/270028
Description: Fluorination of bioactive compounds is an important step in drug discovery and development. Fluorination has been extensively studied in acyclic systems, carbocycles, and fused heterocycles. However, ... More
Reviewed: Reviewed
Date: 2013
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/277896
Description: 1 page(s)
Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/277821
Description: BINAP aminophosphines are prevalent N,P-bidentate, chiral ligands for asymmetric catalysis. While modification via the BINAP-nitrogen linkage is well explored and has provided a diverse body of deriva ... More
Reviewed: Reviewed