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Date: 2016
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1116179
Description: 4 page(s)
Reviewed: Reviewed
Date: 2016
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1116393
Description: Importance: The programmed death 1 (PD-1) pathway limits immune responses to melanoma and can be blocked with the humanized anti-PD-1 monoclonal antibody pembrolizumab. Objective: To characterize the ... More
Reviewed: Reviewed
Date: 2016
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1111811
Description: Purpose We evaluated atypical response patterns and the relationship between overall survival and best overall response measured per immune-related response criteria (irRC) and Response Evaluation Cri ... More
Reviewed: Reviewed
Date: 2016
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1196734
Description: Purpose: Expression of programmed death-ligand 1 (PD-L1) is a potential predictive marker for response and outcome after treatment with anti–programmed death 1 (PD-1). This study explored the relation ... More
Reviewed: Reviewed
Authors: Akbani, Rehan | Akdemir, Kadir C | Baboud, Julien | Gomez-Fernandez, Carmen | Gribbin, Thomas | Grimsby, Jonna | Gross, Benjamin | Guin, Ranabir | Gutschner, Tony | Hadjipanayis, Angela | Halaban, Ruth | Hanf, Benjamin | Haussler, David | Balasundaram, Miruna | Haydu, Lauren E | Hayes, D. Neil | Hayward, Nicholas K | Heiman, David I | Herbert, Lynn | Herman, James G | Hersey, Peter | Hoadley, Katherine A | Hodis, Eran | Holt, Robert A | Balu, Saianand | Hoon, Dave S. B | Hoppough, Susan | Hoyle, Alan P | Huang, Franklin W | Huang, Mei | Huang, Sharon | Hutter, Carolyn M | Ibbs, Matthew | Iype, Lisa | Jacobsen, Anders | Barnabas, Nandita | Jakrot, Valerie | Janning, Alyssa | Jeck, William R | Jefferys, Stuart R | Jensen, Mark A | Jones, Corbin D | Jones, Steven J. M | Ju, Zhenlin | Kakavand, Hojabr | Kang, Hyojin | Bartlett, John | Kefford, Richard F | Khuri, Fadio R | Kim, Jaegil | Kirkwood, John M | Klode, Joachim | Korkut, Anil | Korski, Konstanty | Krauthammer, Michael | Kucherlapati, Raju | Kwong, Lawrence N | Bartlett, Pam | Kycler, Witold | Ladanyi, Marc | Lai, Phillip H | Laird, Peter W | Lander, Eric | Lawrence, Michael S | Lazar, Alexander J | Łaźniak, Radoslaw | Lee, Darlene | Lee, Jeffrey E | Bastian, Boris C | Lee, Junehawk | Lee, Kenneth | Lee, Semin | Lee, William | Leporowska, Ewa | Leraas, Kristen M | Li, Haiyan I | Lichtenberg, Tara M | Lichtenstein, Lee | Lin, Pei | Baylin, Stephen B | Ling, Shiyun | Liu, Jia | Liu, Ouida | Liu, Wenbin | Long, Georgina V | Lu, Yiling | Ma, Singer | Ma, Yussanne | Mackiewicz, Andrzej | Mahadeshwar, Harshad S | Behera, Madhusmita | Malke, Jared | Mallery, David | Manikhas, Georgy M | Mann, Graham J | Marra, Marco A | Matejka, Brenna | Mayo, Michael | Mehrabi, Sousan | Meng, Shaowu | Meyerson, Matthew | Belyaev, Dmitry | Mieczkowski, Piotr A | Miller, John P | Miller, Martin L | Mills, Gordon B | Moiseenko, Fedor | Moore, Richard A | Morris, Scott | Morrison, Carl | Morton, Donald L | Moschos, Stergios | Aksoy, B. Arman | Benz, Christopher | Mose, Lisle E | Muller, Florian L | Mungall, Andrew J | Murawa, Dawid | Murawa, Pawel | Murray, Bradley A | Nezi, Luigi | Ng, Sam | Nicholson, Dana | Noble, Michael S | Bernard, Brady | Osunkoya, Adeboye | Owonikoko, Taofeek K | Ozenberger, Bradley A | Pagani, Elena | Paklina, Oxana V | Pantazi, Angeliki | Parfenov, Michael | Parfitt, Jeremy | Park, Peter J | Park, Woong-Yang | Beroukhim, Rameen | Parker, Joel S | Passarelli, Francesca | Penny, Robert | Perou, Charles M | Pihl, Todd D | Potapova, Olga | Prieto, Victor G | Protopopov, Alexei | Quinn, Michael J | Radenbaugh, Amie | Bir, Natalie | Rai, Kunal | Ramalingam, Suresh S | Raman, Ayush T | Ramirez, Nilsa C | Ramirez, Ricardo | Rao, Uma | Rathmell, W. Kimryn | Ren, Xiaojia | Reynolds, Sheila M | Roach, Jeffrey | Black, Aaron D | Robertson, A. Gordon | Ross, Merrick I | Roszik, Jason | Russo, Giandomenico | Saksena, Gordon | Saller, Charles | Samuels, Yardena | Sander, Chris | Sander, Cindy | Sandusky, George | Bodenheimer, Tom | Santoso, Netty | Saul, Melissa | Saw, Robyn P. M | Schadendorf, Dirk | Schein, Jacqueline E | Schultz, Nikolaus | Schumacher, Steven E | Schwallier, Charles | Scolyer, Richard A | Seidman, Jonathan | Boice, Lori | Sekhar, Pedamallu Chandra | Sekhon, Harmanjatinder S | Senbabaoglu, Yasin | Seth, Sahil | Shannon, Kerwin F | Sharpe, Samantha | Sharpless, Norman E | Shaw, Kenna R. Mills | Shelton, Candace | Shelton, Troy | Boland, Genevieve M | Shen, Ronglai | Sheth, Margi | Shi, Yan | Shiau, Carolyn J | Shmulevich, Ilya | Sica, Gabriel L | Simons, Janae V | Sinha, Rileen | Sipahimalani, Payal | Sofia, Heidi J | Bono, Riccardo | Soloway, Matthew G | Song, Xingzhi | Sougnez, Carrie | Spillane, Andrew J | Spychala, Arkadiusz | Stretch, Jonathan R | Stuart, Joshua | Suchorska, Wiktoria M | Sucker, Antje | Sumer, S. Onur | Bootwalla, Moiz S | Sun, Yichao | Synott, Maria | Tabak, Barbara | Tabler, Teresa R | Tam, Angela | Tan, Donghui | Tang, Jiabin | Tarnuzzer, Roy | Tarvin, Katherine | Tatka, Honorata | Albert, Monique | Bosenberg, Marcus | Taylor, Barry S | Teresiak, Marek | Thiessen, Nina | Thompson, John F | Thorne, Leigh | Thorsson, Vesteinn | Trent, Jeffrey M | Triche Jr., Timothy J | Tsai, Kenneth Y | Tsou, Peiling | Bowen, Jay | Van Den Berg, David J | Van Allen, Eliezer M | Veluvolu, Umadevi | Verhaak, Roeland G | Voet, Douglas | Voronina, Olga | Walter, Vonn | Walton, Jessica S | Wan, Yunhu | Wang, Yuling | Bowlby, Reanne | Wang, Zhining | Waring, Scot | Watson, Ian R | Weinhold, Nils | Weinstein, John N | Weisenberger, Daniel J | White, Peter | Wilkerson, Matthew D | Wilmott, James S | Wise, Lisa | Bristow, Christopher A | Wiznerowicz, Maciej | Woodman, Scott E | Wu, Chang-Jiun | Wu, Chia-Chin | Wu, Junyuan | Wu, Ye | Xi, Ruibin | Xu, Andrew Wei | Yang, Da | Yang, Liming | Brockway-Lunardi, Laura | Yang, Lixing | Zack, Travis I | Zenklusen, Jean C | Zhang, Hailei | Zhang, Jianhua | Zhang, Wei | Zhao, Xiaobei | Zhu, Jingchun | Zhu, Kelsey | Zimmer, Lisa | Brooks, Denise | Zmuda, Erik | Zou, Lihua | Brzezinski, Jakub | Bshara, Wiam | Buda, Elizabeth | Burns, William R | Ally, Adrian | Butterfield, Yaron S. N | Button, Michael | Calderone, Tiffany | Cappellini, Giancarlo Antonini | Carter, Candace | Carter, Scott L | Cherney, Lynn | Cherniack, Andrew D | Chevalier, Aaron | Chin, Lynda | Amin, Samirkumar B | Cho, Juok | Cho, Raymond J | Choi, Yoon-La | Chu, Andy | Chudamani, Sudha | Cibulskis, Kristian | Ciriello, Giovanni | Clarke, Amanda | Coons, Stephen | Cope, Leslie | Arachchi, Harindra | Crain, Daniel | Curley, Erin | Danilova, Ludmila | D'Atri, Stefania | Davidsen, Tanja | Davies, Michael A | Delman, Keith A | Demchok, John A | Deng, Qixia A | Deribe, Yonathan Lissanu | Arora, Arshi | Dhalla, Noreen | Dhir, Rajiv | DiCara, Daniel | Dinikin, Michael | Dubina, Michael | Ebrom, J. Stephen | Egea, Sophie | Eley, Greg | Engel, Jay | Eschbacher, Jennifer M | Auman, J. Todd | Fedosenko, Konstantin V | Felau, Ina | Fennell, Timothy | Ferguson, Martin L | Fisher, Sheila | Flaherty, Keith T | Frazer, Scott | Frick, Jessica | Fulidou, Victoria | Gabriel, Stacey B | Ayala, Brenda | Gao, Jianjiong | Gardner, Johanna | Garraway, Levi A | Gastier-Foster, Julie M | Gaudioso, Carmelo | Gehlenborg, Nils | Genovese, Gianicola | Gerken, Mark | Gershenwald, Jeffrey E | Getz, Gad
Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1062489
Description: We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a framew ... More
Reviewed: Reviewed
Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/356528
Description: Monoclonal antibodies against immune checkpoint blockade have proven to be a major success in the treatment of melanoma. The programmed death receptor-1 ligand-1 (PD-L1) expression on melanoma cells i ... More
Full Text: Full Text
Reviewed: Reviewed
Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1057803
Description: Purpose: To evaluate the expression of tumor PD-L1 and changes in tumor-infiltrating lymphocyte (TIL) populations in patients with metastatic melanoma treated with targeted MAPK inhibitors. Experiment ... More
Reviewed: Reviewed
Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1059727
Description: This study evaluated the expression of PD-L1 in immunotherapy-naïve metastatic melanoma patients to determine longitudinal intrapatient concordance and correlate PD-L1 status with clinicopathologic ch ... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/343415
Description: The transcription factor NF-kappaB (NF-kB) is a key regulator of cytokine and chemokine production in melanoma and is responsible for symptoms such as anorexia, fatigue, and weight loss. In addition, ... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/300025
Description: Acquired resistance to BRAF inhibitors often involves MAPK re-activation, yet the MEK inhibitor trametinib showed minimal clinical activity in melanoma patients that had progressed on BRAF-inhibitor t ... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/341707
Description: The purpose of this study is to profile the changes in the serum levels of a range of chemokines, cytokines, and growth and angiogenic factors in MAPK inhibitor-treated metastatic melanoma patients an ... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/304697
Description: Cancer cells commonly undergo chronic endoplasmic reticulum (ER) stress, to which the cells have to adapt for survival and proliferation. We report here that in melanoma cells intrinsic activation of ... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/1107394
Description: Background: Endoplasmic reticulum (ER) stress is characterized by accumulation and aggregation of unfolded and/or misfolded proteins in the ER lumen. Cells respond by activating a range of signaling p ... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/332846
Description: Epigenetic changes are widespread in melanoma and contribute to the pathogenic biology of this disease. In the present study, we show that I-BET151, which belongs to a new class of drugs that target t ... More
Full Text: Full Text
Reviewed: Reviewed