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Date: 2017
Subject Keyword: SNP | mutation | homology modelling | caveolin
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1220442
Description: The caveolin (Cav) family of proteins comprises key constituents of caveolar structures in cell membranes, which are involved in receptor-independent endocytosis and cellular signalling pathways. Thre ... More
Reviewed: Reviewed
Date: 2017
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1253394
Description: Background: Retinal imaging may serve as an alternative approach to monitor brain pathology in Alzheimer’s disease (AD). In this study, we investigated the association between retinal vascular and str ... More
Full Text: Full Text
Reviewed: Reviewed
Date: 2016
Subject Keyword: TrkB | Cyclotraxin B | GSK3β | docking
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1184602
Description: TrkB is a high affinity receptor for the brain derived neurotrophic factor (BDNF) and its phosphorylation stimulates activation of several intracellular signalling pathways linked to cellular growth, ... More
Date: 2016
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1196456
Description: Accumulation of amyloid β (Aβ) and its aggregates in the ageing central nervous system is regarded synonymous to Alzheimer’s disease (AD) pathology. Despite unquestionable advances in mechanistic and ... More
Reviewed: Reviewed
Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/359951
Description: 7,8-dihydroxyflavone (7,8-DHF) is a TrkB receptor agonist, and treatment with this flavonoid derivative brings about an enhanced TrkB phosphorylation and promotes downstream cellular signalling. Flavo ... More
Full Text: Full Text
Reviewed: Reviewed
Date: 2015
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/1062364
Description: Purpose: The serine protease inhibitor, neuroserpin, is predominantly expressed in neural tissues and is well expressed in the vitreous and retina. There is evidence of involvement of proteases in mat ... More
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/309489
Description: Brain-derived neurotrophic factor (BDNF) stimulation of its high-affinity receptor TrkB results in activation of pro-survival cell-signalling pathways that can afford neuroprotection to the retina. Re ... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/325333
Description: Glycogen synthase kinase 3β (GSK3β) is involved in several biochemical processes in neurons regulating cellular survival, gene expression, cell fate determination, metabolism and proliferation. GSK3β ... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/310540
Description: Purpose: The dynamic properties of retinal vessels including pulse wave propagation and pulsatility index provide new perspective in retinal hemodynamic analysis. In this study we utilize a high speed ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/213174
Description: Purpose: To evaluate neuroprotective effects of 7,8-dihydroxyflavone (7,8-DHF) on isolated rat retinal ganglion cells (RGCs) and RGC-5 cells to assess for the activation of TrkB and downstream surviva ... More
Date: 2012
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/213175
Description: Purpose: Retinal ganglion cells (RGCs) undergo degeneration in glaucoma and optic neuritis. Recent studies indicate the involvement of Caveolin (Cav-1) gene locus in the pathogenesis of POAG. Caveolin ... More
Date: 2012
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/213181
Description: 1 page(s)
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