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Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1027025
Description: The treatment of iron deficiency in areas of high malaria transmission is complicated by evidence which suggests that iron deficiency anemia protects against malaria, while iron supplementation increa ... More
Reviewed: Reviewed
Date: 2015
Subject Keyword: ENU | NGS | variants | forward genetics
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/986370
Description: Background: N-ethyl-N-nitrosourea (ENU) mutagen has become the method of choice for inducing random mutations for forward genetics applications. However, distinguishing induced mutations from sequenci ... More
Full Text: Full Text
Reviewed: Reviewed
Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1027032
Description: During blood stage infection, malaria parasites invade, mature, and replicate within red blood cells (RBCs). This results in a regular growth cycle and an exponential increase in the proportion of mal ... More
Reviewed: Reviewed
Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/424211
Description: Many red cell polymorphisms are a result of selective pressure by the malarial parasite. Here, we add another red cell disease to the panoply of erythrocytic changes that give rise to resistance to ma ... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/316050
Description: Background: Malaria treatments are becoming less effective due to the rapid spread of drug resistant parasites. Increased understanding of the host/parasite interaction is crucial in order to develop ... More
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Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/1034247
Description: Many red cell polymorphisms are a result of selective pressure by the malarial parasite. Here we add another red cell disease to the panoply of erythrocytic changes that give rise to resistance to mal ... More
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/339847
Description: The proliferation of large biorepositories and the staggering advances in our ability to analyse large numbers of human genomes relatively quickly and cost-effectively have been important drivers in t ... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: conference paper
Identifier: http://hdl.handle.net/1959.14/341778
Description: Platelets are best known for their roles in hemostasis, but there is accumulating evidence for their importance in immunity and host defence against infection. We have shown that platelets are require ... More
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/315071
Description: The human erythrocyte contains an abundance of the thiol-dependant peroxidase Peroxiredoxin-2 (Prx2), which protects the cell from the pro-oxidant environment it encounters during its 120 days of life ... More
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Reviewed: Reviewed
Authors: Lee, S. Hong | Harold, Denise | Lechner-Scott, Jeannette | Rujescu, Dan | Goate, Alison | Cruchaga, Carlos | Nowotny, Petra | Morris, | Mayo, Kevin | Livingston, Gill | Bass, Nicholas J | Gurling, Hugh | McQuillin, Andrew | Moscato, Pablo | Gwilliam, Rhian | Deloukas, Panagiotis | Nöthen, Markus M | Holmans, Peter | O'Donovan, Michael | Owen, Michael J | Booth, David R | Stewart, Graeme J | Heard, Robert N | Mason, Deborah | Griffiths, Lyn | Broadley, Simon | Brown, Matthew A | Slee, Mark | Nyholt, Dale R | Foote, Simon J | Stankovich, Jim | Taylor, Bruce V | Wiley, James | Bahlo, Melanie | Perreau, Victoria | Field, Judith | Butzkueven, Helmut | Kilpatrick, Trevor J | Rubio, Justin | Goddard, Michael E | Marriott, Mark | Carroll, William M | Kermode, Allan G | Anderson, Carl A | Gordon, Scott D | Guo, Qun | Henders, Anjali K | Lambert, Ann | Kraft, Peter | Kennedy, Stephen H | Zondervan, Krina T | Macgregor, Stuart | Martin, Nicholas G | Missmer, Stacey A | Morris, Andrew P | Painter, Jodie N | Roseman, Fenella | Treloar, Susan A | Wallace, Leanne | Sims, Rebecca | Gerrish, Amy | Williams, Julie | Chapman, Jade | Moskvina, Valentina | Abraham, Richard | Hollingworth, Paul | Hamshere, Marian | Pahwa, Jaspreet Singh | Dowzell, Kimberley | Williams, Amy | Jones, Nicola | Thomas, Charlene | Montgomery, Grant W | Stretton, Alexandra | Morgan, Angharad | Lovestone, Simon | Powell, John | Proitsi, Petroula | Lupton, Michelle K | Brayne, Carol | Rubinsztein, David C | Gill, Michael | Lawlor, Brian | Wray, Naomi R | Lynch, Aoibhinn | Morgan, Kevin | Brown, Kristelle | Passmore, Peter | Craig, David | McGuinness, Bernadette | Todd, Stephen | Holmes, Clive | Mann, David | Smith, A. David | Visscher, Peter M | Love, Seth | Kehoe, Patrick G | Hardy, John | Mead, Simon | Fox, Nick | Rossor, Martin | Collinge, John | Maier, Wolfgang | Jessen, Frank | Heun, Reiner | Scott, Rodney J | Kölsch, Heike | Schürmann, Britta | van den Bussche, Hendrik | Heuser, Isabella | Kornhuber, Johannes | Wiltfang, Jens | Martin, Dichgans | Frölich, Lutz | Hampel, Harald | Hüll, Michael
Date: 2013
Subject Keyword: 110900 Neurosciences
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/288993
Description: Common diseases such as endometriosis (ED), Alzheimer's disease (AD) and multiple sclerosis (MS) account for a significant proportion of the health care burden in many countries. Genome-wide associati ... More
Reviewed: Reviewed
Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/276707
Description: Platelets, as well as regulating blood hemostasis, are an important component of the body's defense against invading microbial pathogens. We previously reported that platelets protect during malaria i ... More
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Reviewed: Reviewed
Date: 2012
Subject Keyword: 110300 Clinical Sciences
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/178623
Description: The blood stage of the plasmodium parasite life cycle is responsible for the clinical symptoms of malaria. Epidemiological studies have identified coincidental malarial endemicity and multiple red blo ... More
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Reviewed: Reviewed
Date: 2012
Subject Keyword: 110300 Clinical Sciences
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/203173
Description: Platelets restrict the growth of intraerythrocytic malaria parasites by binding to parasitized cells and killing the parasite within. Here, we show that the platelet molecule platelet factor 4 (PF4 or ... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/155719
Description: We describe a collection of 11 families with ≥ 2 generations of family members whose condition has been diagnosed as a hematologic malignancy. In 9 of these families there was a significant decrease i ... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295524
Description: Background: Illumina's Infinium SNP BeadChips are extensively used in both small and large-scale genetic studies. A fundamental step in any analysis is the processing of raw allele A and allele B inte ... More
Full Text: Full Text
Reviewed: Reviewed