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Authors:
Nagy, Zsuzsanna
| Kovács, Ilona
| Török, Miklós
| Toth, Dezso
| Vereb, György
| Buzás, Krisztina
| Juhász, István
| Blumberg, Peter M
| Bíró, Tamás
| Czifra, Gabriella
Date: 2014
Subject Keyword:
111200 Oncology and Carcinogenesis
| Ras activator
| Rasgrp3
| human breast cancer
| chemotherapeutic resistance
| Tamoxifen
| trastuzumab
| tumorigenesis
| EGF
| IGF-I
| signaling pathways
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1027185
Description:
Introduction: Ras guanine nucleotide exchange factors (RasGEFs) mediate the activation of the Ras signaling pathway that is over activated in many human cancers. The RasGRP3, an activator of H-Ras and
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Date: 2014
Subject Keyword:
111200 Oncology and Carcinogenesis
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1044278
Description:
5-fluorouracil (5-FU) is the first line component used in colorectal cancer (CRC) therapy however even in combination with other chemotherapeutic drugs recurrence is common. Mutations of the adenomato
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Date: 2013
Subject Keyword:
111200 Oncology and Carcinogenesis
Language: eng
Resource Type: book chapter
Identifier: http://hdl.handle.net/1959.14/300174
Description:
22 page(s)
Authors:
Carlino, Matteo S
| Gowrishankar, Kavitha
| Rizos, Helen
| Saunders, Catherine A. B
| Pupo, Gulietta M
| Snoyman, Stephanie
| Zhang, Xu Dong
| Saw, Robyn
| Becker, Therese M
| Kefford, Richard F
| Long, Georgina V
Date: 2013
Subject Keyword:
111200 Oncology and Carcinogenesis
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/293736
Description:
Inhibitors of the mitogen-activated protein kinases (MAPK), BRAF, and MAP-ERK kinase (MEK) induce tumor regression in the majority of patients with BRAF-mutant metastatic melanoma. The clinical benefi
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Authors:
Klein, Oliver
| Clements, Arthur
| Menzies, Alexander M
| O'Toole, Sandra
| Kefford, Richard F
| Long, Georgina V
Date: 2013
Subject Keyword:
111200 Oncology and Carcinogenesis
| BRAF inhibitor
| Dabrafenib
| Metastatic melanoma
| V600E
| V600R
| Vemurafenib
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294046
Description:
Activating mutations in the BRAF gene occur in approximately 50% of melanomas. More than 70% of BRAF mutations are V600E and 10-30% are V600K. Potent and selective BRAF inhibitors have demonstrated si
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Authors:
Mann, Graham J
| Pupo, Gulietta M
| Synnott, Maria
| Hersey, Peter
| Kefford, Richard F
| Thompson, John F
| Yang, Yee Hwa
| Scolyer, Richard A
| Campain, Anna E
| Carter, Candace D
| Schramm, Sarah-Jane
| Pianova, Svetlana
| Gerega, Sebastien K
| De Silva, Chitra
| Lai, Kenneth
| Wilmott, James S
Date: 2013
Subject Keyword:
110300 Clinical Sciences
| 111200 Oncology and Carcinogenesis
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294242
Description:
Prediction of outcome for melanoma patients with surgically resected macroscopic nodal metastases is very imprecise. We performed a comprehensive clinico-pathologic assessment of fresh-frozen macrosco
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Authors:
Wilmott, J. S
| Menzies, A. M
| Long, G. V
| Haydu, L. E
| Capper, D
| Preusser, M
| Zhang, Y. E
| Thompson, J. F
| Kefford, R. F
| von Deimling, A
| Scolyer, R. A
Date: 2013
Subject Keyword:
111200 Oncology and Carcinogenesis
| biomarker
| BRAF inhibitor
| immunohistochemistry
| melanoma
| targeted therapies
| V600E
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294285
Description:
Background:To examine the association between level and patterns of baseline intra-tumoural BRAF V600E protein expression and clinical outcome of BRAF V600E melanoma patients treated with selective BR
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Authors:
Walters, S
| Maringe, C
| Allemani, C
| Engholm, G
| Fornander, T
| Gjerstorff, M. L
| Johannesen, T. B
| Lawrence, G
| McGahan, C. E
| Middleton, R
| Steward, J
| Tracey, E
| Butler, J
| Turner, D
| Richards, M. A
| Coleman, M. P
| Brostrom, S
| Bryant, H
| Currow, D
| Gavin, A
| Gunnarsson, G
| Hanson, J
| Harper, T
| Rachet, B
| Kaasa, S
| Sherar, M
| Thomas, B
| Barrett-Lee, P
| Bergh, J
| Boyages, J
| Christiansen, P
| Lee, M
| Warnberg, F
Date: 2013
Subject Keyword:
111200 Oncology and Carcinogenesis
| breast cancer
| population-based
| stage
| survival
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/281902
Description:
Background: We investigate whether differences in breast cancer survival in six high-income countries can be explained by differences in stage at diagnosis using routine data from population-based can
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Authors:
Ford, S. J
| Obeidy, P
| Iqbal, T. H
| Alderson, D
| Richardson, D. R
| Tselepis, C
| Lovejoy, D. B
| Bedford, M
| Nichols, L
| Chadwick, C
| Tucker, O
| Lui, G. Y. L
| Kalinowski, D. S
| Jansson, P. J
Date: 2013
Subject Keyword:
111200 Oncology and Carcinogenesis
| cancer
| deferasirox
| iron chelation
| oesophageal cancer
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295640
Description:
Background and Purpose Growing evidence implicates iron in the aetiology of gastrointestinal cancer. Furthermore, studies demonstrate that iron chelators possess potent anti-tumour activity, although
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Authors:
Long, Georgina V
| Wilmott, James S
| Haydu, Lauren E
| Tembe, Varsha
| Sharma, Raghwa
| Rizos, Helen
| Thompson, John F
| Howle, Julie
| Scolyer, Richard A
| Kefford, Richard F
Date: 2013
Subject Keyword:
111200 Oncology and Carcinogenesis
| BRAF inhibitors
| Dabrafenib
| Vemurafenib
| GSK2118436
| Ki-67
| Necrosis
| PLX4032
| RG
| Survival
| TILs
| Tumor-infiltrating lymphocytes
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294203
Description:
Selective BRAF inhibitors (BRAFi) are a standard of care for the treatment of BRAFV600-mutant metastatic melanoma. We analyzed a unique set of serial triplicate human metastatic melanoma tumor biopsie
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Authors:
Klein, Oliver
| Ribas, Antoni
| Chmielowski, Bartosz
| Walker, Grant
| Clements, Arthur
| Long, Georgina V
| Kefford, Richard F
Date: 2013
Subject Keyword:
111200 Oncology and Carcinogenesis
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294060
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Authors:
Grebenik, Ekaterina A
| Nadort, Annemarie
| Zubov, Vitali P
| Klinov, Dmitry V
| Panchenko, Vladislav Y
| Deyev, Sergey M
| Zvyagin, Andrei V
| Generalova, Alla N
| Nechaev, Andrei V
| Sreenivasan, Varun K. A
| Khaydukov, Evgeny V
| Semchishen, Vladimir A
| Popov, Alexey P
| Sokolov, Viktor I
| Akhmanov, Aleksandr S
Date: 2013
Subject Keyword:
111200 Oncology and Carcinogenesis
| upconversion nanoparticle
| breast cancer
| tissue phantom
| human epidermal growth factor receptor 2
| mini-antibody (wild type)
| biomedical optical imaging
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/282759
Description:
Innovative luminescent nanomaterials, termed upconversion nanoparticles (UCNPs), have demonstrated considerable promise as molecular probes for high-contrast optical imaging in cells and small animals
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Authors:
O'Day, Steven J
| Eggermont, Alexander M. M
| Friedlander, Philip
| Garbe, Claus
| Ugurel, Selma
| Collichio, Frances
| Guo, Wei
| Lufkin, Joelle
| Bahcall, Safi
| Vukovic, Vojo
| Hauschild, Axel
| Chiarion-Sileni, Vanna
| Kefford, Richard
| Grob, Jean Jacques
| Mortier, Laurent
| Robert, Caroline
| Schachter, Jacob
| Testori, Alessandro
| Mackiewicz, Jacek
Date: 2013
Subject Keyword:
111200 Oncology and Carcinogenesis
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294302
Description:
Purpose: Elesclomol, an investigational first-in-class compound, induces oxidative stress, triggers mitochondrial-induced apoptosis in cancer cells, and shows synergy with taxanes in tumor models. Fol
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Authors:
Berndt, Sonja I
| Skibola, Christine F
| Lan, Qing
| Laden, Francine
| Giovannucci, Edward
| Kraft, Peter
| Kricker, Anne
| Turner, Jenny
| Vajdic, Claire M
| Ennas, Maria Grazia
| Ferri, Giovanni M
| Miligi, Lucia
| Liang, Liming
| Teras, Lauren R
| Sampson, Joshua
| Crouch, Simon
| Park, Ju-Hyun
| North, Kari E
| Cox, Angela
| Snowden, John A
| Wright, Josh
| Carracedo, Angel
| Lopez-Otin, Carlos
| Bea, Silvia
| Chatterjee, Nilanjan
| Salaverria, Itziar
| Martin-Garcia, David
| Campo, Elias
| Fraumeni Jr, Joseph F
| de Sanjose, Silvia
| Hjalgrim, Henrik
| Cerhan, James R
| Chanock, Stephen J
| Rothman, Nathaniel
| Slager, Susan L
| Chung, Charles C
| Yeager, Meredith
| Brooks-Wilson, Angela R
| Hartge, Patricia
| Purdue, Mark P
| Birmann, Brenda M
| Armstrong, Bruce K
| Joseph, Vijai
| Cocco, Pierluigi
| Zhang, Yawei
| Severi, Gianluca
| Zeleniuch-Jacquotte, Anne
| Lawrence, Charles
| Burdette, Laurie
| Yuenger, Jeffrey
| Hutchinson, Amy
| Jacobs, Kevin B
| Call, Timothy G
| Camp, Nicola J
| Shanafelt, Tait D
| Novak, Anne J
| Kay, Neil E
| Liebow, Mark
| Wang, Alice H
| Smedby, Karin E
| Adami, Hans-Olov
| Melbye, Mads
| Glimelius, Bengt
| Chang, Ellen T
| Nieters, Alexandra
| Glenn, Martha
| Curtin, Karen
| Cannon-Albright, Lisa A
| Jones, Brandt
| Diver, W. Ryan
| Link, Brian K
| Weiner, George J
| Conde, Lucia
| Bracci, Paige M
| Riby, Jacques
| Wang, Zhaoming
| Holly, Elizabeth A
| Smith, Martyn T
| Jackson, Rebecca D
| Tinker, Lesley F
| Benavente, Yolanda
| Becker, Nikolaus
| Boffetta, Paolo
| Brennan, Paul
| Foretova, Lenka
| Maynadie, Marc
| Cozen, Wendy
| McKay, James
| Staines, Anthony
| Rabe, Kari G
| Achenbach, Sara J
| Vachon, Celine M
| Goldin, Lynn R
| Strom, Sara S
| Lanasa, Mark C
| Spector, Logan G
| Leis, Jose F
| Monnereau, Alain
| Cunningham, Julie M
| Weinberg, J. Brice
| Morrison, Vicki A
| Caporaso, Neil E
| Norman, Aaron D
| Linet, Martha S
| De Roos, Anneclaire J
| Morton, Lindsay M
| Severson, Richard K
| Riboli, Elio
| Wang, Sophia S
| Vineis, Paolo
| Kaaks, Rudolph
| Trichopoulos, Dimitrios
| Masala, Giovanna
| Weiderpass, Elisabete
| Chirlaque, Maria-Dolores
| Vermeulen, Roel C. H
| Travis, Ruth C
| Giles, Graham G
| Albanes, Demetrius
| Kelly, Rachel S
| Virtamo, Jarmo
| Weinstein, Stephanie
| Clavel, Jacqueline
| Zheng, Tongzhang
| Holford, Theodore R
| Offit, Kenneth
| Zelenetz, Andrew
| Klein, Robert J
| Spinelli, John J
| Bertrand, Kimberly A
Date: 2013
Subject Keyword:
111200 Oncology and Carcinogenesis
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/274876
Description:
Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptib
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Authors:
Biernacka, K. M
| Uzoh, C. C
| Zeng, L
| Persad, R. A
| Bahl, A
| Gillatt, D
| Perks, C. M
| Holly, J. M. P
Date: 2013
Subject Keyword:
111200 Oncology and Carcinogenesis
| Carcinoma
| Chemotherapy
| IGF
| Obesity
| Prostate
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295607
Description:
Clinically relevant prostate cancer (PCa) is more frequent in Westernised societies and increasingly men have co-morbidities associated with a Western lifestyle, primarily diabetes, characterised by h
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