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Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/271082
Description: Clinical trials that stop early for benefit have a treatment difference that overestimates the true effect. The consequences of this fact have been extensively debated in the literature. Some research ... More
Reviewed: Reviewed
Authors: Marschner, Ian C
Date: 2013
Language: eng
Resource Type: conference paper
Identifier: http://hdl.handle.net/1959.14/280519
Description: The Stochastic EM algorithm is a Monte Carlo method for approximating the regular EM algorithm in missing data situations where the E step is intractable. It produces a stationary Markov chain iterati ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/176317
Description: Relative risks (RRs) are generally considered preferable to odds ratios in prospective studies. However, unlike logistic regression for odds ratios, the standard log-binomial model for RR regression d ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/176942
Description: Risk factor models in clinical epidemiology are important for identifying individuals at high risk of poor health outcomes and for guiding intervention strategies to reduce risk. Such models are often ... More
Reviewed: Reviewed
Authors: Marschner, Ian C
Date: 2011
Subject Keyword: 010400 Statistics
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/162923
Description: The R function glm uses step-halving to deal with certain types of convergence problems when using iteratively reweighted least squares to fit a generalized linear model. This works well in some circu ... More
Reviewed: Reviewed
Authors: Marschner, Ian C
Date: 2010
Subject Keyword: 010400 Statistics
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/114805
Description: Background Multinational clinical trials efficiently pool resources and provide treatment comparisons across diverse populations. However, they may be difficult to interpret when there are larger than ... More
Reviewed: Reviewed
Authors: Marschner, Ian C
Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/114778
Description: Identity link Poisson regression is useful when the mean of a count variable depends additively on a collection of predictor variables. It is particularly important in epidemiology, for modeling absol ... More
Reviewed: Reviewed
Authors: Marschner, Ian C
Date: 2007
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/106266
Description: Clinical trials are often designed to compare several treatments with a common control arm in pairwise fashion. In this paper we study optimal designs for such studies, based on minimizing the total n ... More
Reviewed: Reviewed
Authors: Marschner, Ian C
Date: 2006
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/106280
Description: Drug development in the pharmaceutical industry is increasingly influenced by measures of cost-effectiveness, such as cost per life-year gained, and some governments make decisions about whether to pa ... More
Reviewed: Reviewed
Date: 2006
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/106290
Description: Hypotheses about the mechanisms of action by which a treatment affects a clinical outcome may prompt consideration of an alternative outcome as a potential surrogate. In many cases, due to costs or ot ... More
Reviewed: Reviewed
Date: 2003
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/106293
Description: This paper discusses interim analysis for clinical trials where the primary endpoint is observed at a specific long-term follow-up time, but where repeated measures of the same outcome are also taken ... More
Reviewed: Reviewed
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