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Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294242
Description: Prediction of outcome for melanoma patients with surgically resected macroscopic nodal metastases is very imprecise. We performed a comprehensive clinico-pathologic assessment of fresh-frozen macrosco ... More
Reviewed: Reviewed
Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294285
Description: Background:To examine the association between level and patterns of baseline intra-tumoural BRAF V600E protein expression and clinical outcome of BRAF V600E melanoma patients treated with selective BR ... More
Reviewed: Reviewed
Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/281902
Description: Background: We investigate whether differences in breast cancer survival in six high-income countries can be explained by differences in stage at diagnosis using routine data from population-based can ... More
Reviewed: Reviewed
Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295640
Description: Background and Purpose Growing evidence implicates iron in the aetiology of gastrointestinal cancer. Furthermore, studies demonstrate that iron chelators possess potent anti-tumour activity, although ... More
Reviewed: Reviewed
Authors: Berndt, Sonja I | Skibola, Christine F | Lan, Qing | Laden, Francine | Giovannucci, Edward | Kraft, Peter | Kricker, Anne | Turner, Jenny | Vajdic, Claire M | Ennas, Maria Grazia | Ferri, Giovanni M | Miligi, Lucia | Liang, Liming | Teras, Lauren R | Sampson, Joshua | Crouch, Simon | Park, Ju-Hyun | North, Kari E | Cox, Angela | Snowden, John A | Wright, Josh | Carracedo, Angel | Lopez-Otin, Carlos | Bea, Silvia | Chatterjee, Nilanjan | Salaverria, Itziar | Martin-Garcia, David | Campo, Elias | Fraumeni Jr, Joseph F | de Sanjose, Silvia | Hjalgrim, Henrik | Cerhan, James R | Chanock, Stephen J | Rothman, Nathaniel | Slager, Susan L | Chung, Charles C | Yeager, Meredith | Brooks-Wilson, Angela R | Hartge, Patricia | Purdue, Mark P | Birmann, Brenda M | Armstrong, Bruce K | Joseph, Vijai | Cocco, Pierluigi | Zhang, Yawei | Severi, Gianluca | Zeleniuch-Jacquotte, Anne | Lawrence, Charles | Burdette, Laurie | Yuenger, Jeffrey | Hutchinson, Amy | Jacobs, Kevin B | Call, Timothy G | Camp, Nicola J | Shanafelt, Tait D | Novak, Anne J | Kay, Neil E | Liebow, Mark | Wang, Alice H | Smedby, Karin E | Adami, Hans-Olov | Melbye, Mads | Glimelius, Bengt | Chang, Ellen T | Nieters, Alexandra | Glenn, Martha | Curtin, Karen | Cannon-Albright, Lisa A | Jones, Brandt | Diver, W. Ryan | Link, Brian K | Weiner, George J | Conde, Lucia | Bracci, Paige M | Riby, Jacques | Wang, Zhaoming | Holly, Elizabeth A | Smith, Martyn T | Jackson, Rebecca D | Tinker, Lesley F | Benavente, Yolanda | Becker, Nikolaus | Boffetta, Paolo | Brennan, Paul | Foretova, Lenka | Maynadie, Marc | Cozen, Wendy | McKay, James | Staines, Anthony | Rabe, Kari G | Achenbach, Sara J | Vachon, Celine M | Goldin, Lynn R | Strom, Sara S | Lanasa, Mark C | Spector, Logan G | Leis, Jose F | Monnereau, Alain | Cunningham, Julie M | Weinberg, J. Brice | Morrison, Vicki A | Caporaso, Neil E | Norman, Aaron D | Linet, Martha S | De Roos, Anneclaire J | Morton, Lindsay M | Severson, Richard K | Riboli, Elio | Wang, Sophia S | Vineis, Paolo | Kaaks, Rudolph | Trichopoulos, Dimitrios | Masala, Giovanna | Weiderpass, Elisabete | Chirlaque, Maria-Dolores | Vermeulen, Roel C. H | Travis, Ruth C | Giles, Graham G | Albanes, Demetrius | Kelly, Rachel S | Virtamo, Jarmo | Weinstein, Stephanie | Clavel, Jacqueline | Zheng, Tongzhang | Holford, Theodore R | Offit, Kenneth | Zelenetz, Andrew | Klein, Robert J | Spinelli, John J | Bertrand, Kimberly A
Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/274876
Description: Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptib ... More
Reviewed: Reviewed
Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/299864
Description: Inositol polyphosphate 5-phosphatases can terminate downstream signalling of phosphatidylinositol-3 kinase; however, their biological role in the pathogenesis of cancer is controversial. Here we repor ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294740
Description: Cellular senescence permanently restricts the replicative capacity of cells in response to various stress signals, including aberrant activation of oncogenes. The presence of predictive senescence mar ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294544
Description: Aberrant activation of the BRAF kinase occurs in ~60% of melanomas, and although BRAF inhibitors have shown significant early clinical success, acquired resistance occurs in most patients. Resistance ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294694
Description: The development of acquired drug resistance hampers the long-term success of B-RAF inhibitor therapy for melanoma patients. Here we show V600E B-RAF copy-number gain as a mechanism of acquired B-RAF i ... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295249
Description: Background: We assess the prognostic value of chemotherapy-induced leukopenia and sensory neuropathy in the CALYPSO trial patients treated with carboplatin-paclitaxel (CP) or carboplatin-liposomal dox ... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295306
Description: The bioavailability of orally administered imatinib is 90%, although the drug is monocationic under the acidic conditions in the duodenum. In vitro, we found that imatinib is transported by the intest ... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/296087
Description: We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control indiv ... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295796
Description: Background: The development of androgen independence, chemo-, and radioresistance are critical markers of prostate cancer progression and the predominant reasons for its high mortality. Understanding ... More
Reviewed: Reviewed