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Date: 2016
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1074386
Description: The APP-PS1ΔE9 mouse model of Alzheimer's disease (AD) exhibits age dependent amyloid β (Aβ) plaque formation in their central nervous system due to high expression of mutated human APP and PSEN1 tran ... More
Reviewed: Reviewed
Date: 2016
Subject Keyword: TrkB | Cyclotraxin B | GSK3β | docking
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1184602
Description: TrkB is a high affinity receptor for the brain derived neurotrophic factor (BDNF) and its phosphorylation stimulates activation of several intracellular signalling pathways linked to cellular growth, ... More
Date: 2016
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1196456
Description: Accumulation of amyloid β (Aβ) and its aggregates in the ageing central nervous system is regarded synonymous to Alzheimer’s disease (AD) pathology. Despite unquestionable advances in mechanistic and ... More
Reviewed: Reviewed
Date: 2015
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/1062364
Description: Purpose: The serine protease inhibitor, neuroserpin, is predominantly expressed in neural tissues and is well expressed in the vitreous and retina. There is evidence of involvement of proteases in mat ... More
Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1053684
Description: Purpose: We evaluated the performance of low contrast achromatic (LLA) multifocal visual evoked potentials (mfVEP) in preperimetric glaucoma and compared its diagnostic performance to other early diag ... More
Reviewed: Reviewed
Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/357877
Description: Introduction: Visual evoked potential (VEP) latency prolongation and optic nerve lesion length after acute optic neuritis (ON) corresponds to the degree of demyelination, while subsequent recovery of ... More
Full Text: Full Text
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/309489
Description: Brain-derived neurotrophic factor (BDNF) stimulation of its high-affinity receptor TrkB results in activation of pro-survival cell-signalling pathways that can afford neuroprotection to the retina. Re ... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/325333
Description: Glycogen synthase kinase 3β (GSK3β) is involved in several biochemical processes in neurons regulating cellular survival, gene expression, cell fate determination, metabolism and proliferation. GSK3β ... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/342502
Description: Purpose: To evaluate the correlation of corneal biomechanical parameters to structural characteristics in normal, forme fruste keratoconic, keratoconic and collagen crosslinked eyes. The study was bas ... More
Date: 2014
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/342514
Description: Purpose: To evaluate the sensitivity and specificity of Ocular Response Analyser (ORA) indices: Keratoconus Match Index (KMI) and Keratoconus Match Probability (KMP) in distinguishing forme fruste ker ... More
Date: 2013
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/289169
Description: 2 page(s)
Date: 2013
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/289259
Description: 1 page(s)
Date: 2012
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/213174
Description: Purpose: To evaluate neuroprotective effects of 7,8-dihydroxyflavone (7,8-DHF) on isolated rat retinal ganglion cells (RGCs) and RGC-5 cells to assess for the activation of TrkB and downstream surviva ... More
Date: 2012
Language: eng
Resource Type: conference paper abstract
Identifier: http://hdl.handle.net/1959.14/213175
Description: Purpose: Retinal ganglion cells (RGCs) undergo degeneration in glaucoma and optic neuritis. Recent studies indicate the involvement of Caveolin (Cav-1) gene locus in the pathogenesis of POAG. Caveolin ... More