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Authors: Lee, S. Hong | Harold, Denise | Lechner-Scott, Jeannette | Rujescu, Dan | Goate, Alison | Cruchaga, Carlos | Nowotny, Petra | Morris, | Mayo, Kevin | Livingston, Gill | Bass, Nicholas J | Gurling, Hugh | McQuillin, Andrew | Moscato, Pablo | Gwilliam, Rhian | Deloukas, Panagiotis | Nöthen, Markus M | Holmans, Peter | O'Donovan, Michael | Owen, Michael J | Booth, David R | Stewart, Graeme J | Heard, Robert N | Mason, Deborah | Griffiths, Lyn | Broadley, Simon | Brown, Matthew A | Slee, Mark | Nyholt, Dale R | Foote, Simon J | Stankovich, Jim | Taylor, Bruce V | Wiley, James | Bahlo, Melanie | Perreau, Victoria | Field, Judith | Butzkueven, Helmut | Kilpatrick, Trevor J | Rubio, Justin | Goddard, Michael E | Marriott, Mark | Carroll, William M | Kermode, Allan G | Anderson, Carl A | Gordon, Scott D | Guo, Qun | Henders, Anjali K | Lambert, Ann | Kraft, Peter | Kennedy, Stephen H | Zondervan, Krina T | Macgregor, Stuart | Martin, Nicholas G | Missmer, Stacey A | Morris, Andrew P | Painter, Jodie N | Roseman, Fenella | Treloar, Susan A | Wallace, Leanne | Sims, Rebecca | Gerrish, Amy | Williams, Julie | Chapman, Jade | Moskvina, Valentina | Abraham, Richard | Hollingworth, Paul | Hamshere, Marian | Pahwa, Jaspreet Singh | Dowzell, Kimberley | Williams, Amy | Jones, Nicola | Thomas, Charlene | Montgomery, Grant W | Stretton, Alexandra | Morgan, Angharad | Lovestone, Simon | Powell, John | Proitsi, Petroula | Lupton, Michelle K | Brayne, Carol | Rubinsztein, David C | Gill, Michael | Lawlor, Brian | Wray, Naomi R | Lynch, Aoibhinn | Morgan, Kevin | Brown, Kristelle | Passmore, Peter | Craig, David | McGuinness, Bernadette | Todd, Stephen | Holmes, Clive | Mann, David | Smith, A. David | Visscher, Peter M | Love, Seth | Kehoe, Patrick G | Hardy, John | Mead, Simon | Fox, Nick | Rossor, Martin | Collinge, John | Maier, Wolfgang | Jessen, Frank | Heun, Reiner | Scott, Rodney J | Kölsch, Heike | Schürmann, Britta | van den Bussche, Hendrik | Heuser, Isabella | Kornhuber, Johannes | Wiltfang, Jens | Martin, Dichgans | Frölich, Lutz | Hampel, Harald | Hüll, Michael
Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/288993
Description: Common diseases such as endometriosis (ED), Alzheimer's disease (AD) and multiple sclerosis (MS) account for a significant proportion of the health care burden in many countries. Genome-wide associati... More
Reviewed:Reviewed
Date: 2013
Subject Keyword: MD Multidisciplinary
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/288671
Description: Genome-wide association studies (GWAS) have identified around 60 common variants associated with multiple sclerosis (MS), but these loci only explain a fraction of the heritability of MS. Some missing... More
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Reviewed:Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295524
Description: Background: Illumina's Infinium SNP BeadChips are extensively used in both small and large-scale genetic studies. A fundamental step in any analysis is the processing of raw allele A and allele B inte... More
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Reviewed:Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/305446
Description: Objective: To perform a 1-stage meta-analysis of genome-wide association studies (GWAS) of multiple sclerosis (MS) susceptibility and to explore functional consequences of new susceptibility loci. Met... More
Reviewed:Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/155523
Description: Background: HLA-DRB1*1501 (DR15) and other HLA class II alleles increase the risk of developing multiple sclerosis (MS). However, the contribution of genetic heterogeneity to the clinical course of MS... More
Reviewed:Reviewed
Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/157468
Description: A family history of a haematological malignancy (HM) is known to be a risk factor for HMs. However, collections of large families with multiple cases of varied disease types are relatively rare. We de... More
Reviewed:Reviewed
Date: 2010
Subject Keyword: MD Multidisciplinary
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294016
Description: It is well established that Multiple Sclerosis (MS) is an immune mediated disease. Little is known about what drives the differential control of the immune system in MS patients compared to unaffected... More
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Reviewed:Reviewed
Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/171743
Description: Recent association studies in multiple sclerosis (MS) have identified and replicated several single nucleotide polymorphism (SNP) susceptibility loci including CLEC16A, IL2RA, IL7R, RPL5, CD58, CD40 a... More
Reviewed:Reviewed
Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294130
Description: As of June 2009, 361 genome-wide association studies (GWAS) had been referenced by the HuGE database. GWAS require DNA from many thousands of individuals, relying on suitable DNA collections. We recen... More
Reviewed:Reviewed
Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294221
Description: Multiple sclerosis (MS) is an autoimmune disease with a genetic component, caused at least in part by aberrant lymphocyte activity. The whole blood mRNA transcriptome was measured for 99 untreated MS ... More
Reviewed:Reviewed
Date: 2009
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/171808
Description: Low-voltage-activated, or T-type, calcium (Ca2+) channels are believed to play an essential role in the generation of absence seizures in the idiopathic generalized epilepsies (IGEs). We describe a ho... More
Reviewed:Reviewed
Date: 2009
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/157496
Description: BACKGROUND: The influence of APOE allelic heterogeneity on multiple sclerosis (MS) disease severity has been reported in multiple datasets with conflicting results. Several studies have reported an un... More
Reviewed:Reviewed