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Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294242
Description: Prediction of outcome for melanoma patients with surgically resected macroscopic nodal metastases is very imprecise. We performed a comprehensive clinico-pathologic assessment of fresh-frozen macrosco ... More
Reviewed: Reviewed
Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/293967
Description: BACKGROUND: The programmed death 1 (PD-1) receptor is a negative regulator of T-cell effector mechanisms that limits immune responses against cancer. We tested the anti-PD-1 antibody lambrolizumab (pr ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294537
Description: BACKGROUND: Resistance to therapy with BRAF kinase inhibitors is associated with reactivation of the mitogen-activated protein kinase (MAPK) pathway. To address this problem, we conducted a phase 1 an ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294530
Description: Dabrafenib is an inhibitor of BRAF kinase that is selective for mutant BRAF. We aimed to assess its safety and tolerability and to establish a recommended phase 2 dose in patients with incurable solid ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/179123
Description: Purpose: Temsirolimus is an effective treatment for renal cell carcinoma. It is associated with increases in serum cholesterol, triglyceride, and glucose. We investigated whether changes of these biom ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294694
Description: The development of acquired drug resistance hampers the long-term success of B-RAF inhibitor therapy for melanoma patients. Here we show V600E B-RAF copy-number gain as a mechanism of acquired B-RAF i ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294733
Description: BACKGROUND: Approximately 50% of melanomas harbor activating (V600) mutations in the serine-threonine protein kinase B-RAF (BRAF). The oral BRAF inhibitor vemurafenib (PLX4032) frequently produced tum ... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/160577
Description: Background: In the setting of metastatic colorectal cancer (CRC), anti-EGFR antibodies are not currently recommended for individuals with KRAS mutant tumours. This is based on subgroup analyses of ind ... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/223536
Description: Activation of the aryl hydrocarbon receptor (AHR) by environmental xenobiotic toxic chemicals, for instance 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), has been implicated in a variety of cellular p ... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294845
Description: 4 page(s)
Reviewed: Reviewed
Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294887
Description: 4 page(s)
Reviewed: Reviewed
Date: 2009
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295864
Description: We report a genome-wide association study of melanoma conducted by the GenoMEL consortium based on 317K tagging SNPs for 1,650 selected cases and 4,336 controls, with replication in an additional two ... More
Reviewed: Reviewed
Date: 2009
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/277188
Description: Docetaxel chemotherapy improves symptoms and survival in men with metastatic hormone-refractory prostate cancer (HRPC). However, ∼50% of patients do not respond to Docetaxel and are exposed to signifi ... More
Reviewed: Reviewed
Authors: Eeles, Rosalind A | Kote-Jarai, Zsofia | Schleutker, Johanna | Easton, Douglas F | Bollina, Prasad | Bonnington, Sue | Cooper, Debbie | Doble, Andrew | Doherty, Alan | Durkan, Garrett | Elliott, Emma | Gillatt, David | Herbert, Pippa | Hamdy, Freddie C | Holding, Peter | Howson, Joanne | Jones, Mandy | Kockelbergh, Roger | Kynaston, Howard | Lennon, Teresa | Lyons, Norma | Leung, Hing | Moody, Hilary | Powell, Philip | Neal, David E | Prescott, Stephen | Thompson, Pauline | Fisher, Cyril | Jameson, Charles | Barrett, Sandra | Kelham, Penelope | Brown, Paul M | George, Anne | Marsden, Gemma | Davis, Michael | Donovan, Jenny L | Wallace, David M. A | Bhatt, R. I | Subramonian, K | Arrand, John | Flanagan, Louise | Bradley, Sita Ann | Pedersen, John | Smith, Charmaine | Bagnato, Melisa | Nelson, Colleen | Stanford, Janet L | O'Mara, Tracy | Hinze, Kimberly | VandenBergh, Patrica | Newman, Beth | Nicol, David | Yaxley, John | Ferguson, Megan | Stankovich, James | Thomson, Russell | Foote, Simon | Ostrander, Elaine A | Challis, David | McArdle, John | McKay, James | Banks, Annette | McWhirter, Rebekah | Butorac, Kate | Smark, Heidi | Blizzard, Leigh | Popov, Elenko | Kachakova, Darina | Ingles, Sue A | Dodova, Rumjana | Belcheva, Olga | Nikolov, Momchil | Mitev, Vanio | Vlahova, Aleksandrina | Dikov, Tihomir | Christova, Svetlana | Hamel, Nancy | Kotar, Kimberley | Hou, Jian-Guo | John, Esther M | Xu, Dan-Feng | Chang, Wen-Jun | Xu, Xing-Xing | Stenman, Ulf-Håkan | Mattila, Henna | Siltanen, Sanna | Pakkanen, Sanna | Isotalo, Jarkko | Matikainen, Mika | Surowy, Harald | Thibodeau, Stephen N | Brugger, Margot | Wiest, Irina | Weber, Bärbel | Herkommer, Kathleen | Paiss, Thomas | Kuefer, Rainer | Dubrowinskaja, Natalia | von Klot, Christoph | Kuczyk, Markus | Hillemanns, Peter | Schaid, Daniel | Bremer, Michael | Karstens, Johann H | Machtens, Stefan | Biedermann, Cédric | Peter, Hans-Ulrich | Defabiani, Nicolas | Bieri, Sabine | Girardet, Christophe | Konzelmann, Isabelle | Stalder, Michèle | Al Olama, Ali Amin | Park, Jong Y | Meier, Marie-Mathilde | Wang, Liang | Cunningham, Julie | Zuhlke, Kimberly A | Johnson, Emilie K | Montie, James E | Zakariah, Babu | Park, Hyun Y | Radein, Selina | Rincon, Maria | Spurdle, Amanda | Zachariah, Babu | Zeigler-Johnson, Charnita | Spangler, Elaine | Coomes, Margerie | Gallagher, Stephen | Walker, Amy | Cohen, N. P | Conn, I | Swami, Kuchibhotla S | Moffat, Leslie E. F | Clements, Judith | Kenwrick, Sue | Patterson, Helen | Waite, Katherine | Wiles, Vicki | Irwin, C | Lancashire, M | Ellis, B. W | Kulkarni, Ravi | Gurun, Riza Murat | Hollins, Graham W | Dickinson, Joanne L | Mahmood, Rana | Meddings, Robert N | Briggs, Tim | Chong, Irene | Gelister, James S | Mumtaz, Faiz | Ravi, Ramachandran | Malone, Peter R | Pengelly, A | Dodds, David | Maier, Christiane | Featherston, C | Hendry, David | Jones, Gareth | Kirk, David | Russell, John M | Siva, M | Leader, Mary | Thomas, Robert J | Morrison, Patrick | O'Sullivan, Joe | Vogel, Walther | Shum, L | Stewart, D | Feggetter, Jeremy | O'Brien, J | Cole, Trevor | Cruger, Dorthe | Maher, E. R | Neilson, Donald | Wemyss-Holden, G. D | Susnerwala, Shabbir | Dork, Thilo | Bahl, Amit | Persad, Raj | Wright, Mark | Zang, Angelika | Leone, Priscilla | Tahir, Saad | Parikh, Omi | Virdi, Jaspal | Izegbu, Victor | Bellringer, James | Rebbeck, Timothy R | Falconer, Alison | Carter, Simon | Hrouda, D | Karp, Stephen J | Bower, Mark | Dinneen, Michael | Brock, Cathryn | Gilbert, Hugh | Jenkins, P | Cooney, Kathleen A | Boucher, Nigel R | James, Michael J | Cowan, Richard | Evans, D. Gareth | Livsey, Jacqueline | Logue, John | Wylie, James P | Lalloo, Fiona | Sugden, Elaine | Brewster, Simon F | Cannon-Albright, Lisa | Cole, David J | Connell, C | Protheroe, Andrew | Saxby, M. F | Ryan, P. G | Peake, David | Coe, M | Errington, R. D | Ibrahim, A | Syndikus, Isabel | Giles, Graham G | Chappuis, Pierre O | Booth, C. M | Corr, John | Lynch, Michael | Callaghan, P. S | Plail, R | Ash, D | Coyle, C | Bottomley, David | Powell, Christopher | Chilton, Christopher | Hutter, Pierre | Henley, Mike | Peracha, A. M | Williams, John H | Williams, Simon | Muthukumar, D | Thomas, Stephen A | Dickinson, Andrew J | Hammonds, John | McInerney, Paul | Pascoe, Sarah | Zeegers, Maurice | Sells, Henry | Tyrell, C. J | Tindall, Stuart F | Afzal, N | Andrews, Steven | Cornaby, Andrew J | Archbold, J. A. A | Kunkler, Ian H | Folkes, A | Money-Kyrle, Julian | Kaneva, Radka | Bax, N. A | Lawrence, W. T | McKinna, F | Rimington, Peter R | Dawson, Chris | Khan, F | Charig, C | Le Roux, Pieter J | Hehir, Michael | Smith, Michael F | Zhang, Hong-Wei | Tweedle, James | Glenister, James | Eden, C. D | Langley, Stephen E. M | Montgomery, Bruce | Naerger, Harry | Palfrey, Edward | Wilson, Richard | Qureshi, Khaver N | Apakama, Ike | Lu, Yong-Jie | Prasad, Krishna | Al-Samerraie, Dr | Emmerson, Louise | Nethersell, A | Srinivasan, Mr | Glaholm, John | Ohja, Hemant | Dahar, Nazeer | Daruwala, Pallon | Beck, Rupert | Foulkes, William D | Iacovou, John W | Harper, Peter | Perry, Matthew | Popert, Rick | Cahill, D | Dobbs, H. Jane | Izatt, Louise | O'Brien, Tim S | Tong, Dr | Kelkar, Anand R | English, Dallas R | Waxman, J. H | Badenoch, David | O'Donoghue, Neil | Singh, Pravin | Lawson, Anne | Pancharatnam, M | Shah, Nihil | Sole, Graham M | Pope, A. J | Clarke, Noel W | Leongamornlert, Daniel A | Ferro, Michael | Harney, John M | Douglas, S. Fiona | Banerjee, G | Donaldson, P | Scrase, Christopher | Chadwick, David | Hardman, P. D. John | Hindmarsh, John R | Suresh, Gokarakonda | Tymrakiewicz, Malgorzata | Mithal, Natasha | Murray, Keith W | Davison, Owen W | Baxter-Smith, D | Motiwala, Hanif | Barber, N | Muir, Gordon | Copland, Robert F | Dick, John | Morley, Roland | Guy, Michelle | Morrison, Jonathan | Butterworth, Paul C | Griffiths, Thomas R. L | Osborn, David | Terry, T | Barwell, Julian | Trembath, Richard C | Javle, Pradip | Basu, Pradip | Mark, I | Panades, Miguel | Ardern-Jones, Audrey T | Sreenivasan, Thiagarajan | Hanbury, Damien C | McNicholas, T. A | Davidson, S | Holden, David | Namasivayam, Siva | Reddy, Paul J | Beesley, Sharon | Ford, Trevor F | Lewis, J | Hall, Amanda L | Chetiyawardana, Anula D | Smith, James | Mufti, Gulzar | Andrews, Henry | Walker, E. M | Anjum, Iqbal | Bose, Pradeep | Lucas, Malcolm G | Ashford, Richard F. U | Dickson, Jeanette | O'Brien, Lynne T | Hoskin, Peter | Hughes, Rob | Ostler, Peter | Churn, Mark J | Cooke, Peter | Inglis, John A | Philp, N. H | Waymont, Brian | McMenemin, Rhona | Pedley, I | Wilkinson, Rosemary A | Roberts, J. Trevor | Lee, J. O | Ho, Edwin T. S | Irving, Stuart | Mills, Robert | Sethia, Krishna K | Webb, Ralph J | Sheehan, Denise J | Barnes, Douglas G | Chow, Wai-Man | Saunders, Edward J | Costello, C. B | Elwell, Christine | Elkabir, Jeremy | Fermont, D | Mee, A. David | Bishop, M | Cole, O | Harriss, D. R | Lemburger, R .John | Sokal, Michael | Page, Elizabeth C | Sundar, Santhanam | Dunn, Michael | Urwin, Graeme H | Benson, Richard | Baria, Dr | Memon, Mr | Biyani, C. Shekhar | Browning, Tony J | Murphy, Michael | Sundaram, S. K | Sawyer, Emma J | Weston, P. M. T | Goode, Thomas D | Hickish, Tamas | Castle, Bruce M | Cummings, Mr | Eccles, Diana | Harvey-Hills, N | Mort, Diana | Menzes, Pravin | Ahmed, Munir | Edwards, Stephen M | Dawkins, Guy | El-Modir, A | Hughes, Michael | Luscombe, C. J | James, N | Hampson, S. J | Gibbs, Stephanie | Chakraborti, P | Kumar, M | Whillis, D | Dearnaley, David P | Kourah, Mohamed | Parys, Bohdan T | Lau, Maurice W | Brown, Richard | Fawcett, Derek | Rogers, P. B | Lee, L | Mobb, Gillian E | Pantelides, Michalakis L | Bramble, F. James | Severi, Gianluca | Horwich, Alan | Brock, Sue | Carter, Charles J. M | Davies, Joseph | McBride, Donna | Rundle, John | Wedderburn, Andrew | Collinson, Matthew | Cox, Robert | Ellis, R | Newton, R | Huddart, Robert A | O'Rourke, J. S | Thomson, Alastair H | Wheatley, Duncan | Stott, Mark A | Pocock, Richard D | Rankin, Julia | Crundwell, Malcolm | Kaisary, Amir | Pigott, Katharine | Bates, Christopher A | Khoo, Vincent S | Beese, Gail | Bowsher, W. G | Carter, Adam C | Gower, Richard L | Anderson, John | Harrison, G. S. M | Adamson, Andrew | Duffy, Peter | Rowbotham, Carl | Woolfenden, K. A | Parker, Christopher C | Cornford, P. A | Bancroft, E | Jhavar, Sameer | Locke, Imogen | Mitra, Anita | Shanley, Sue | Wynne, Chris | Sharma, Neerah K | Birtle, Alison | Mokete, Moeketsi | Van As, Nicholas | Ragavan, Narasimhan | Read, Graham | Watson, M. E | Wise, Marcus | Blades, Rosemary | Matenhelia, Shyam | Beacock, Christopher | Elves, Andrew W. S | Srihari, Narayanan N | Birch, Brian | Woodhouse, Christopher J | Heath, Catherine M | Laing, Robert | Bloomfield, David J | Coker, C | Deutsch, George P | Fletcher, Matthew | Larner, T. R | Murrell, Shirley | Nawrocki, Jan | Robinson, Angus | Thompson, Alan | Wilkins, Marie | Frim, Olivera | Gallegos, Christopher | Howell, Graham P | McFarlane, Jonathan | Newman, Hugh | Samanci, Ali | Campbell, Alister | Guy, Peter J | McIntosh, Gregor | Christmas, Tim | Hamilton, C | Hawkyard, Simon | Robertson, Andrew | Coombs, L | Dixit, Sanjay | Morris, Sean B | Ball, Andrew J | Carr, T. W | Koreich, O | Lodge, Richard | Ogden, Chris | Prejbisz, J. W | Robinson, Anne C | Abrams, Paul H | Corolis, Mr | Drake, Mr | Graham, John | Rowe, Edward | Keeley, F. X | McGrath, John | Schwaibold, Hartwig | Cooper, Colin S | Vesey, Sean | Thurston, A | Watkin, Nicholas A | Chinegwundoh, F. I | Lee, A | Mair, Graeme H. M | Nargund, Vinod | Oliver, Tim | Plowman, P. Nicholas | Anson, Ken | Muir, Kenneth | Southey, Melissa C | Hodgson, Shirley | Saggar, Anand K | Bailey, M. J | Gordon, E. M | Taylor, John W | Boyd, P. J. R | Jones, Chris R | Walker, Roger | Joss, Shelagh | Whelan, P | Lophatananon, Artitaya | Aparcia, F | Hudson, Liz | Patel, Anup | Holmes, Simon A. V | Dunsmuir, W. D | Beaney, Ronald P | Calman, Frances | Glass, Jonathan M | Simcock, R | James, R. Lester | Liu, Jo-Fen | Rao, Y | Scoble, John E | Adeyoju, A | Brown, Stephen | Collins, Gerald | Oakley, Neil | O'Reilly, P | Lloyd, S | Alcock, Christopher | Greenland, Jonathan | Kolonel, Laurence N | Green, Damian | Brough, Richard | O'Boyle, P. J | Macdonagh, Ruaraidh P | Speakman, Mark J | Violet, John | Mostafid, Amir H | Kirby, Roger S | Kirollos, Magdi M | Lydon, Anna | Le Marchand, Loic | MacDermott, James P. A | Mason, Robert | Carnell, Dawn M | Emberton, Mark | Harland, Stephen J | O'Donoghue, E | Payne, Heather | Duchesne, Gill M | Blacklock, A. R. E | Desai, Ken M | Wahlfors, Tiina | Grieve, Robert | Humber, Caroline | Sriram, Rajagopalan | Stockdale, Andrew | Willis, Michael | Worlding, Jane | Bailey, Karen | Murray, Alexandra | Datta, Shibendra | Hughes, Owen | Tammela, Teuvo L | Matthews, Philip N | Barber, Jim | Lester, Jason | Mason, M. D | Rowley, Kathryn | Tilsley, Owen | Longmuir, Mark | Robinson, Lee Q | Jones, David A | Lewis, D. Christopher | Auvinen, Anssi | Strachan, John R | Crisp, John C | Mitchell, S | Sherwin, Elizabeth | McLaren, Duncan | Tulloch, David N | Ferguson, C | Kirkbride, Peter | Karim, O | Lewis, Sarah J | Laniado, Marc | Philp, T | Wells, Paula | Beard, Ralph | Liston, Thomas | Woodhams, Simon | De Bolla, Alan R | Kelleher, J. P | Weaver, Andrew | Parker, Christopher H | Cox, Angela | Porter, Tim | Stower, M. J | Wilson, J. R | Ahiaku, Ernest K. N | Hopper, John L | Fitzgerald, Liesel M | Koopmeiners, Joseph S | Karyadi, Danielle M | Kwon, Erika M | Stern, Mariana C | Corral, Roman | Joshi, Amit D | Shahabi, Ahva | McDonnell, Shannon K | Sellers, Thomas A | Henderson, Brian E | Pow-Sang, Julio | Chambers, Suzanne | Aitken, Joanne | Gardiner, R. A. (Frank) | Batra, Jyotsna | Kedda, Mary Anne | Lose, Felicity | Polanowski, Andrea | Patterson, Briony | Serth, Jürgen | Haiman, Christopher A | Meyer, Andreas | Luedeke, Manuel | Stefflova, Klara | Ray, Anna M | Lange, Ethan M | Farnham, Jim | Khan, Humera | Slavov, Chavdar | Mitkova, Atanaska | Cao, Guangwen
Date: 2009
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/305231
Description: Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study ... More
Reviewed: Reviewed