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Date: 2016
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1200751
Description: Background: It is unknown whether melanoma patients achieving complete response (CR) with targeted therapy can safely discontinue treatment. Methods: All patients treated with BRAF/MEK inhibitors achi ... More
Reviewed: Reviewed
Authors: Law, Matthew H | Bishop, D. Timothy | Pharoah, Paul D. P | Vilalta, Antonio | Calista, Donato | Landi, Giorgio | Minghetti, Paola | Arcangeli, Fabio | Bertazzi, Pier Alberto | Pastorino, Lorenza | Bruno, William | Andreotti, Virginia | Martinuzzi, Claudia | Swerdlow, Anthony J | Battistuzzi, Linda | Origone, Paola | Queirolo, Paola | Affleck, Paul | Harrison, Jane | Whittaker, Linda | Kukalizch, Kairen | Leake, Susan | Karpavicius, Birute | Haynes, Sue | Kypreou, Katerina P | Mack, Tricia | Chan, May | Taylor, Yvonne | Davies, John | King, Paul | van Nieuwpoort, Frans A | Out, Coby | van der Drift, Clasine | Bergman, Wilma | Kukutsch, Nicole | Taylor, John C | Bouwes Bavinck, Jan Nico | Bakker, Bert | ter Huurne, Jeanet | van der Rhee, Han | Bekkenk, Marcel | Snels, Dyon | van Praag, Marinus | Brochez, Lieve | Gerritsen, Rianne | Crijns, Marianne | Harland, Mark | Vasen, Hans | van Workum, Wilbert | Janssen, Bart | Janssen, Marjolein | Mulder, Suzanne | Jönsson, Göran | Borg, Åke | Måsbäck, Anna | Lundgren, Lotta | Baeckenhorn, Katja | Randerson-Moor, Juliette | Nielsen, Kari | Schmidt Casslén, Anita | Rootwelt, Helge | Bressac-de Paillerets, Brigitte | Maubec, Eve | Brossard, Myriam | Vaysse, Amaury | Mohamdi, Hamida | Jeannin, Patricia | Chaudru, Valérie | Akslen, Lars A | Chateigner, Nicolas | Corda, Eve | Lesueur, Fabienne | de Lichy, Mahaut | Andry-Benzaquen, Pascale | Bachollet, Bertrand | Bérard, Frédéric | Berthet, Pascaline | Boitier, Françoise | Bonadona, Valérie | Andresen, Per A | Bonafé, Jean-Louis | Bonnetblanc, Jean-Marie | Cambazard, Frédéric | Caron, Olivier | Caux, Frédéric | Chevrant-Breton, Jacqueline | Chompret, Agnès | Dalle, Stéphane | Demange, Liliane | Dereure, Olivier | Avril, Marie-Françoise | Doré, Martin-Xavier | Doutre, Marie-Sylvie | Dugast, Catherine | Faivre, Laurence | Grange, Florent | Humbert, Philippe | Joly, Pascal | Kerob, Delphine | Lasset, Christine | Leccia, Marie Thérèse | Azizi, Esther | Lenoir, Gilbert | Leroux, Dominique | Levang, Julien | Lipsker, Dan | Mansard, Sandrine | Martin, Ludovic | Martin-Denavit, Tanguy | Mateus, Christine | Michel, Jean-Loïc | Morel, Patrice | Lee, Jeffrey E | Bianchi Scarrà, Giovanna | Olivier-Faivre, Laurence | Perrot, Jean-Luc | Robert, Caroline | Ronger-Savle, Sandra | Sassolas, Bruno | Souteyrand, Pierre | Stoppa-Lyonnet, Dominique | Thomas, Luc | Vabres, Pierre | Wierzbicka, Eva | Brown, Kevin M | Knorr, Jilian | Ming, Michael | Mitra, Nandita | Ruffin, Althea | Van Belle, Patricia | Lubiński, Jan | Mirecka, Aneta | Ertmański, Sławomir | Hocevar, Marko | Peric, Barbara | Dȩbniak, Tadeusz | Cerkovnik, Petra | Kefford, Richard F | Schmid, Helen | Holland, Elizabeth A | Galore-Haskel, Gilli | Baron-Epel, Orna | Scope, Alon | Pavlotsky, Felix | Yakobson, Emanuel | Cohen-Manheim, Irit | Duffy, David L | Laitman, Yael | Milgrom, Roni | Shimoni, Iris | Kozlovaa, Evgeniya | Aitken, Joanne F | Armstrong, Bruce K | Giles, Graham G | Hopper, John L | Jenkins, Mark A | Visscher, Peter | Elder, David E | Webb, Penny | Green, Adele | Parsons, Peter | Purdie, David | Zhao, Zhen Zhen | Henders, Anjali K | Stark, Mitchell | Painter, Jodie N | Pavey, Sandra | Gotley, David | Fang, Shenying | Smithers, Mark | Drew, Paul | Jamieson, Glyn | Watson, David | Clouston, Andrew | Nancarrow, D | Hussey, D | Smith, E | Mayne, G | O'Brien, S | Friedman, Eitan | Sadkowsky, T | McMurtrie, A | Terry, L | Connard, M | Jackman, L | Perry, S | Davis, M | Roffe, D | Martin, M | Smith, L | Galan, Pilar | Brown, I | Walker, N | Bessell, Justin | Tam, William | Ruskowicz, Andrew | Hemminki, Kari | Sucker, Antje | Vogt, Thomas | Gutzmer, Ralf | Gogas, Helen | Ghiorzo, Paola | Hoon, David | Nagore, Eduardo | Kirkwood, John | Weide, Benjamin | Rutkowski, Piotr | Ugurel, Selma | Karagianni, Fani | Antonopoulou, Kyriaki | Polydorou, Dorothea | Hasapi, Vasiliki | Gillanders, Elizabeth M | Plaka, Michaela | Gousetti, Nelli | Papadopoulos, Othon | Antoniou, Christina | Evangelou, Vangelis | Goldstein, Alisa M | Gruis, Nelleke A | Hansson, Johan | Helsing, Per | Hočevar, Marko | Höiom, Veronica | Ingvar, Christian | Kanetsky, Peter A | Chen, Wei V | Landi, Maria Teresa | Martin, Nicholas G | Lang, Julie | Lathrop, G. Mark | Mackie, Rona M | Mann, Graham J | Molven, Anders | Montgomery, Grant W | Novaković, Srdjan | Olsson, Håkan | Puig, Susana | Moses, Eric K | Puig-Butille, Joan Anton | Qureshi, Abrar A | Radford-Smith, Graham L | van der Stoep, Nienke | van Doorn, Remco | Whiteman, David C | Craig, Jamie E | Schadendorf, Dirk | Simms, Lisa A | Burdon, Kathryn P | Song, Fengju | Nyholt, Dale R | Pooley, Karen A | Orr, Nick | Stratigos, Alexander J | Cust, Anne E | Ward, Sarah V | Hayward, Nicholas K | Han, Jiali | Schulze, Hans-Joachim | Dunning, Alison M | Barrett, Jennifer H | Newton Bishop, Julia A | Demenais, Florence | Amos, Christopher I | MacGregor, Stuart | Iles, Mark M | Aguilera, Paula | Alejo, Beatriz | Badenas, Celia | Caño, Abel | Carrera, Cristina | Kumar, Rajiv | Cuellar, Francisco | Dominguez, Mireia | Gabriel, Daniel | Gimenez-Xavier, Pol | Iglesias, Pablo | Malvehy, Josep | Marti-Laborda, Rosa | Mila, Montse | Ogbah, Zighe | Potrony, Miriam | Easton, Douglas F | Tell, Gemma | Alós, Llúcia | Arance, Ana | Arguís, Pedro | Bennassar, Antonio | Chirife, Oscar | Conill, Carlos | Rull, Ramon | Sánchez, Marcelo | Vidal-Sicart, Sergi
Date: 2015
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1070416
Description: Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide associ ... More
Reviewed: Reviewed
Date: 2014
Subject Keyword: biomarker | HGF | melanoma | RAF inhibitor
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/1112020
Description: Of more than 150 000 published studies evaluating new biomarkers, fewer than 100 biomarkers have been implemented for patient care. One reason for this is lack of rigorous testing by the medical commu ... More
Reviewed: Reviewed
Date: 2014
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/332713
Description: One-third of BRAF-mutant metastatic melanoma patients treated with combined BRAF and MEK inhibition progress within 6 months. Treatment options for these patients remain limited. Here we analyse 20 BR ... More
Reviewed: Reviewed
Date: 2013
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294242
Description: Prediction of outcome for melanoma patients with surgically resected macroscopic nodal metastases is very imprecise. We performed a comprehensive clinico-pathologic assessment of fresh-frozen macrosco ... More
Reviewed: Reviewed
Date: 2013
Subject Keyword: 110300 Clinical Sciences
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/293557
Description: Approximately 50% of melanomas require oncogenic B-RAF V600E signaling for proliferation, survival, and metastasis, and the use of highly selective B-RAF inhibitors has yielded remarkable, although sh ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294740
Description: Cellular senescence permanently restricts the replicative capacity of cells in response to various stress signals, including aberrant activation of oncogenes. The presence of predictive senescence mar ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294544
Description: Aberrant activation of the BRAF kinase occurs in ~60% of melanomas, and although BRAF inhibitors have shown significant early clinical success, acquired resistance occurs in most patients. Resistance ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294694
Description: The development of acquired drug resistance hampers the long-term success of B-RAF inhibitor therapy for melanoma patients. Here we show V600E B-RAF copy-number gain as a mechanism of acquired B-RAF i ... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/296087
Description: We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control indiv ... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294845
Description: 4 page(s)
Reviewed: Reviewed
Date: 2010
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294887
Description: 4 page(s)
Reviewed: Reviewed
Date: 2009
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/295864
Description: We report a genome-wide association study of melanoma conducted by the GenoMEL consortium based on 317K tagging SNPs for 1,650 selected cases and 4,336 controls, with replication in an additional two ... More
Reviewed: Reviewed