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Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294579
Description: Background: Brain metastases are common in patients with metastatic melanoma and median overall survival from their diagnosis is typically 17-22 weeks. We assessed dabrafenib in patients with Val600Gl ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294593
Description: Purpose: Certain clinicopathologic features correlate with BRAF mutation status in melanoma including younger age and primary subtype. This study sought to determine the BRAF mutation status by age-de ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294551
Description: Making cancer drugs affordable requires coherent policy and cannot be left to market forces.
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294768
Description: Targeted therapies are increasingly being used to treat a variety of cancers. Their efficacy depends upon the accurate detection and targeting of a specific mutation or aberration in the tumor. All ca ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294516
Description: The contribution of melanocortin-1 receptor (MC1R) gene variants to the development of early-onset melanoma is unknown. Using an Australian population-based, case-control-family study, we sequenced MC ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294558
Description: Background The incidence of melanoma in Australia continues to rise. Early diagnosis and management before the melanoma has metastasised provides the best opportunity for a favourable outcome. Objecti ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294694
Description: The development of acquired drug resistance hampers the long-term success of B-RAF inhibitor therapy for melanoma patients. Here we show V600E B-RAF copy-number gain as a mechanism of acquired B-RAF i ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294565
Description: BACKGROUND: A history of multiple primary melanomas (PMs) has been associated with improved survival in patients with early stage melanoma, but whether it also is correlated with survival in patients ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294688
Description: BRAF inhibitors (BRAFi) induce antitumor responses in nearly 60% of patients with advanced V600E/KBRAF melanomas. Somatic activating MEK1 mutations are thought to be rare in melanomas, but their poten ... More
Reviewed: Reviewed
Date: 2012
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294754
Description: Purpose: To evaluate the effects of treatment with the potent mutant BRAF inhibitors GSK2118436 or vemurafenib (PLX4720) on immune responses to metastatic melanoma in tissues taken before and after tr ... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/294831
Description: Objective: To examine associations between early-life sun exposure and risk of invasive cutaneous melanoma diagnosed between ages 18 and 39 years. Methods: Data were analysed from 606 cases and 481 co ... More
Reviewed: Reviewed
Authors: Amos, Christopher I | Wang, Li-E | Schacherer, Christopher W | Taylor, John C | Whittaker, Linda | Kukalizch, Kairen | Leake, Susan | Karpavicius, Birute | Haynes, Sue | Mack, Tricia | Chan, May | Taylor, Yvonne | Davies, John | Gardner, Julie M | King, Paul | Gruis, Nelleke A | van Nieuwpoort, Frans A | Out, Coby | van der Drift, Clasine | Bergman, Wilma | Kukutsch, Nicole | Bouwes Bavinck, Jan Nico | Bakker, Bert | van der Stoep, Nienke | Wang, Yuling | ter Huurne, Jeanet | van der Rhee, Han | Bekkenk, Marcel | Snels, Dyon | van Praag, Marinus | Brochez, Lieve | Gerritsen, Rianne | Crijns, Marianne | Vasen, Hans | Olsson, Håkan | Bishop, D. Tim | Ingvar, Christian | Jönsson, Göron | Borg, Åke | Måsbäck, Anna | Lundgren, Lotta | Baeckenhorn, Katja | Nielsen, Kari | Schmidt Casslén, Anita | Helsing, Per | Andresen, Per Arne | Barrett, Jennifer H | Rootwelt, Helge | Akslen, Lars | Molven, Anders | Avril, Marie-Françoise | Bressac-de Paillerets, Brigitte | Chaudru, Valérie | Chateigner, Nicolas | Corda, Eve | Jeannin, Patricia | Lesueur, Fabienne | MacGregor, Stuart | de Lichy, Mahaut | Maubec, Eve | Mohamdi, Hamida | Demenais, Florence | Andry-Benzaquen, Pascale | Bachollet, Bertrand | Bérard, Frédéric | Berthet, Pascaline | Boitier, Françoise | Bonadona, Valére | Hayward, Nicholas K | Bonafé, Jean-Louis | Bonnetblanc, Jean-Marie | Cambazard, Frédéric | Caron, Olivier | Caux, Frédéric | Chevrant-Breton, Jacqueline | Chompret, Angès | Dalle, Stéphane | Demange, Liliane | Dereure, Olivier | Martin, Nicholas G | Doré, Martin-Xavier | Doutre, Marie-Sylvie | Dugast, Catherine | Faivre, Laurence | Grange, Florent | Humbert, Philippe | Joly, Pascal | Kerob, Delphine | Lasset, Christine | Leccia, Marie Thérèse | Duffy, David L | Lenoir, Gilbert | Leroux, Dominique | Levang, Julien | Lipsker, Dan | Mansard, Sandrine | Martin, Ludovic | Martin-Denavit, Tanguy | Mateus, Christine | Michel, Jean- Loïc | Morel, Patrice | Mann, Graham J | Olivier-Faivre, Laurence | Perrot, Jean-Luc | Robert, Caroline | Ronger-Savle, Sandra | Sassolas, Bruno | Souteyrand, Pierre | Stoppa-Lyonnet, Dominique | Thomas, Luc | Vabres, Pierre | Wierzbicka, Eva | Lee, Jeffrey E | Cust, Anne | Elder, David | Kanetsky, Peter | Knorr, Jillian | Ming, Michael | Mitra, Nandita | Ruffin, Althea | Van Belle, Patricia | Dębniak, Tadeusz | Lubiński, Jan | Mirecka, Aneta | Hopper, John | Ertmański, Sławomir | Novakovic, Srdjan | Hocevar, Marko | Peric, Barbara | Cerkovnik, Petra | Höiom, Veronica | Hansson, Johan | Holland, Elizabeth A | Azizi, Esther | Galore-Haskel, Gilli | Brown, Kevin M | Friedman, Eitan | Baron-Epel, Orna | Scope, Alon | Pavlotsky, Felix | Yakobson, Emanuel | Cohen-Manheim, Irit | Laitman, Yael | Milgrom, Roni | Shimoni, Iris | Kozlovaa, Evgeniya | Grimm, Elizabeth A | Xu, Yaji | Han, Younghun | Jing, Kaiyan | McHugh, Caitlin | Laurie, Cathy C | Doheny, Kim F | Gershenwald, Jeffrey E | Pugh, Elizabeth W | Seldin, Michael F | Han, Jiali | Wei, Qingyi | Aitken, Joanne F | Armstrong, Bruce K | Giles, Graham G | Kefford, Richard F | Chen, Wei V | Jenkins, Mark A | Schmid, Helen | Aguilera, Paula | Badenas, Celia | Carrera, Cristina | Cuellar, Francisco | Gabriel, Daniel | Martinez, Estefania | Gonzalez, Melinda | Fang, Shenying | Iglesias, Pablo | Malvehy, Josep | Marti-Laborda, Rosa | Mila, Montse | Ogbah, Zighe | Puig Butille, Joan-Anton | Puig, Susana | Alós, Llúcia | Arance, Ana | Arguís, Pedro | Kosoy, Roman | Campo, Antonio | Castel, Teresa | Conill, Carlos | Palou, Jose | Rull, Ramon | Sánchez, Marcelo | Vidal-Sicart, Sergi | Vilalta, Antonio | Vilella, Ramon | Montgomery, Grant W | Zhang, Mingfeng | Whiteman, David C | Webb, Penny | Green, Adele | Parsons, Peter | Purdie, David | Landi, Maria Teresa | Calista, Donato | Landi, Giorgio | Minghetti, Paola | Arcangeli, Fabio | Qureshi, Abrar A | Bertazzi, Pier Alberto | Bianchi-Scarra, Giovanna | Ghiorzo, Paola | Pastorino, Lorenza | Bruno, William | Battistuzzi, Linda | Gargiulo, Sara | Nasti, Sabina | Gliori, Sara | Origone, Paola | Vattathil, Selina | Andreotti, Virginia | Queirolo, Paola | Mackie, Rona | Lang, Julie | Newton Bishop, Julia A | Affleck, Paul | Harrison, Jane | Iles, Mark M | Randerson-Moor, Juliette | Harland, Mark
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/305992
Description: We performed a multistage genome-wide association study of melanoma. In a discovery cohort of 1804 melanoma cases and 1026 controls, we identified loci at chromosomes 15q13.1 (HERC2/OCA2 region) and 1 ... More
Reviewed: Reviewed
Date: 2011
Language: eng
Resource Type: journal article
Identifier: http://hdl.handle.net/1959.14/296087
Description: We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control indiv ... More
Reviewed: Reviewed