Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/87570
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- Title
- Metabolic fate of intravenously administered N-acetylneuraminic acid-6-¹⁴C in newborn piglets
- Related
- Asia Pacific journal of clinical nutrition, Vol. 16, Issue 1, p.110-115
- Related
- http://apjcn.nhri.org.tw/server/APJCN/Volume16/vol16.1/Finished/Wang.pdf
- Publisher
- HEC Press
- Date
- 2007
- FoR/RFCD Code(s)
-
111100 Nutrition and Dietetics
- Author/Creator
- Wang, Bing
- Author/Creator
- Downing, Jeff A
- Author/Creator
- Petocz, Peter
- Author/Creator
- Brand-Miller, Jennie
- Author/Creator
- Bryden, Wayne L
- Description
- Background: Sialic acid (N-acetylneuraminic acid), a component of gangliosides and sialylglycoproteins, may be a conditional nutrient in early life because endogenous synthesis is limited. The aim of this study was to investigate the metabolic fate of intravenously administrated N-acetylneuraminic acid 6¹⁴C (sialic acid) in piglets. Method: Three-day-old male domestic piglets (Sus scrofa) were injected via the jugular vein with 5 µCi (11-12x10⁶ cpm) of N-acetylneuraminic acid-6¹⁴C (specific activity of 55 mCi/mmol). Blood samples were collected at regular intervals over the next 120 min. The organs were then removed and the urine collected for determination of residual radioactivity. Results: Within 2 min of injection, 80% of the activity was removed from the blood and by 120 min the remaining activity approached 8%. At 120 min, the brain contained significantly more radioactivity (cpm/g tissue) than the liver, pancreas, heart and spleen, but less than the kidneys. Within the brain, the percentage of total injected activity was highest in the cerebrum (0.175 ± 0.008) followed by the cerebellum (0.0295 ± 0.006, p = 0.00006) and the thalamus (0.029 ± 0.006, p = 0.00003). Conclusions: An exogenous source of sialic acid is capable of crossing the blood-brain barrier and being taken up into various tissues. The findings suggest that dietary sources of sialic acid may contribute to early brain development in newborn mammals.
- Description
- 6 page(s)
- Subject Keyword
- 111100 Nutrition and Dietetics
- Subject Keyword
- N-acetylneuraminic acid 6-¹⁴C
- Subject Keyword
- intravenous administration
- Subject Keyword
- brain
- Subject Keyword
- metabolic fate
- Subject Keyword
- newborn piglets
- Resource Type
- journal article
- Organisation
- Macquarie University. Dept. of Statistics
- Identifier
- http://hdl.handle.net/1959.14/87570
- Identifier
- ISSN:1440-6047
- Identifier
- mq-rm-2007002021
- Language
- eng
- Reviewed
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