Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/83674
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- Title
- Local anaesthetics for acute reversible blockade of the sympathetic baroreflex in the rat
- Related
- Journal of neuroscience methods, Vol. 179, Issue 1, p.58-62
- DOI
- 10.1016/j.jneumeth.2009.01.012
- Publisher
- Elsevier
- Date
- 2009
- FoR/RFCD Code(s)
-
060603 Animal Physiology - Systems
110901 Autonomic Nervous System
110903 Central Nervous System
- Author/Creator
- Farnham, Melissa M. J
- Author/Creator
- Pilowsky, Paul M
- Description
- Sinoaortic denervation is a common method used in the investigation of function in the cardiovascular system. In the rat, this is usually accomplished by transection of the carotid sinus and aortic depressor nerves, which is permanent. We propose a novel, and simple method for acute baroreceptor denervation in the rat in which the region around the carotid sinuses is superfused with local anaesthetic agents. We demonstrate that complete baroreceptor denervation can be achieved for longer (bupivacaine, 30–60 min) or shorter (lignocaine, 10–30 min) periods, without harming the physiological state of the rat.
- Description
- 5 page(s)
- Subject Keyword
- 060603 Animal Physiology - Systems
- Subject Keyword
- 110901 Autonomic Nervous System
- Subject Keyword
- 110903 Central Nervous System
- Subject Keyword
- Sinoaortic denervation
- Subject Keyword
- Bupivacaine
- Subject Keyword
- Lignocaine
- Subject Keyword
- Carotid sinus
- Resource Type
- journal article
- Organisation
- Macquarie University. Australian School of Advanced Medicine
- Identifier
- http://hdl.handle.net/1959.14/83674
- Identifier
- ISSN:0165-0270
- Identifier
- mq-rm-2009003926
- Language
- eng
- Reviewed
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