Identification of the new UV filter compound cysteine-L-3-hydroxkynurenine O-β-D-glucoside in human lenses | Macquarie University ResearchOnline

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Title: Identification of the new UV filter compound cysteine-L-3-hydroxkynurenine O-β-D-glucoside in human lenses
Related: Febs letters, Vol. 580, Issue 21, p.5071-5076
DOI: 10.1016/j.febslet.2006.08.026
Publisher: Elsevier Science
Date: 2006
Author/Creator: Hains, Peter G
Author/Creator: Mizdrak, Jasminka
Author/Creator: Streete, Isla M
Author/Creator: Jamie, Joanne F
Author/Creator: Truscott, Roger J. W
Description: UV filters protect the human lens and retina from UV light-induced damage. Here, we report the identification of a new UV filter, cysteine-l-3-hydroxykynurenine O-β-d-glucoside, which is present in older normal human lenses. Its structure was confirmed by independent synthesis. It is likely this novel UV filter is formed in the lens by nucleophilic attack of cysteine on the unsaturated ketone derived from deamination of 3-hydroxykynurenine O-β-d-glucoside. Quantitation studies revealed considerable variation in normal lens levels that may be traced to the marked instability of the cysteine adduct. The novel UV filter was not detected in advanced nuclear cataract lenses.
Description: 6 page(s)
Subject Keyword: UV filters
Subject Keyword: cysteine
Subject Keyword: lens
Subject Keyword: cataract
Resource Type: journal article
Organisation: Macquarie University. Dept. of Chemistry and Biomolecular Sciences

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