Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/74513
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- Title
- ß-amyloid imaging and memory in non-demented individuals : evidence for preclinical Alzheimer's disease
- Related
- Brain, Vol. 130, Issue 11, p.2837-2844
- DOI
- 10.1093/brain/awm238
- Publisher
- Oxford University Press
- Date
- 2007
- FoR/RFCD Code(s)
-
110300 Clinical Sciences
110900 Neurosciences
170100 Psychology
- Author/Creator
- Pike, Kerryn E
- Author/Creator
- Savage, Greg
- Author/Creator
- Villemagne, Victor L
- Author/Creator
- Ng, Stephen
- Author/Creator
- Moss, Simon A
- Author/Creator
- Maruff, Paul
- Author/Creator
- Mathis, Chester A
- Author/Creator
- Klunk, William E
- Author/Creator
- Masters, Colin L
- Author/Creator
- Rowe, Christopher C
- Description
- β-amyloid (Aβ) deposition is pathognomic for Alzheimer’s disease (AD), but may occur in normal elderly people without apparent cognitive effect. Episodic memory impairment is an early and prominent sign of AD, but its relationship with Aβ burden in non-demented persons and in AD patients is unclear.We examined this relationship using ¹¹C-PIB-PET as a quantitative marker of Aβ burden in vivo in healthy ageing (HA), mild cognitive impairment (MCI) and AD. Thirty-one AD, 33 MCI and 32 HA participants completed neuropsychological assessment and a ¹¹C-PIB-PET brain scan. Multiple linear regression analyses were conducted relating episodic memory performance and other cognitive functions to Aβ burden. Ninety-seven percent of AD, 61% of MCI and 22% of HA cases had increased cortical PIB binding, indicating the presence of Aβ plaques.There was a strong relationship between impaired episodic memory performance and PIB binding, both in MCI and HA. This relationship was weaker in AD and less robust for non-memory cognitive domains. Aβ deposition in the asymptomatic elderly is associated with episodic memory impairment. This finding, together with the strong relationship between PIB binding and the severity of memory impairment in MCI, suggests that individuals with increased cortical PIB binding are on the path to Alzheimer’s disease. The data also suggests that early intervention trials for AD targeted to non-demented individuals with cerebral Aβ deposition are warranted.
- Description
- 8 page(s)
- Subject Keyword
- 110300 Clinical Sciences
- Subject Keyword
- 110900 Neurosciences
- Subject Keyword
- 170100 Psychology
- Subject Keyword
- memory performance
- Subject Keyword
- Alzheimer’s disease
- Subject Keyword
- mild cognitive impairment
- Subject Keyword
- beta-amyloid
- Subject Keyword
- PET imaging
- Resource Type
- journal article
- Organisation
- Macquarie University. Macquarie Centre for Cognitive Science
- Identifier
- http://hdl.handle.net/1959.14/74513
- Identifier
- ISSN:0006-8950
- Identifier
- mq-rm-2007000945
- Language
- eng
- Reviewed
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