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- Title
- Replication of reported linkages for dyslexia and spelling and suggestive evidence for novel regions on chromosomes 4 and 17
- Related
- European journal of human genetics, Vol. 15, Issue 2, p.194-203
- DOI
- 10.1038/sj.ejhg.5201739
- Publisher
- Nature Publishing Group
- Date
- 2007
- Author/Creator
- Bates, Timothy C
- Author/Creator
- Luciano, Michele
- Author/Creator
- Castles, Anne
- Author/Creator
- Coltheart, Max
- Author/Creator
- Wright, Margaret J
- Author/Creator
- Martin, Nicholas G
- Description
- We report the first genome-wide linkage analysis for reading and spelling in a sample of 403 families of twins, aged between 12 and 25 years taken from the normal population and unselected for reading ability. These traits showed heritabilities of 0.52–0.73, and support for linkage exceeded replication levels (lod>1.44) of seven of the 11 linkages reported in dyslexic samples, namely: 2q22.3, 3p12-q13, 6q11.2, 7q32, 15q21.1, 18p21, and Xq27.3. For five of these (2q22.3, 6q11.2, 7q32, 18p21, and Xq27), this study provides the first independent replication. 1p34–36 and 2p15–16 received some support, with lods of 1.2 and 0.83, respectively, whereas two regions received little support (6p23–21.3 and 11p15.5). This study also identified two novel linkages at 4p15.33-16.1 and 17p13.3, which received suggestive support (max. lod 2.08 and 1.99, respectively).
- Description
- 10 page(s)
- Subject Keyword
- 170103 Educational Psychology
- Subject Keyword
- dyslexia
- Subject Keyword
- language disorder
- Subject Keyword
- reading
- Subject Keyword
- spelling
- Subject Keyword
- linkage
- Subject Keyword
- DYX
- Resource Type
- journal article
- Organisation
- Macquarie University. Macquarie Centre for Cognitive Science
- Identifier
- http://hdl.handle.net/1959.14/46773
- Identifier
- ISSN:1018-4813
- Identifier
- mq-rm-2006006538
- Language
- eng
- Reviewed
Macquarie University ResearchOnline
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