Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/8232
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- Title
- The effects of L-Glucose on memory in mice are modulated by peripherally acting cholinergic drugs
- Related
- Neurobiology of learning and memory, Vol. 77, Issue 1, p.17-28
- DOI
- 10.1006/nlme.2000.4001
- Publisher
- Academic Press
- Date
- 2002
- Author/Creator
- Lawson, Catherine J
- Author/Creator
- Homewood, Judi
- Author/Creator
- Taylor, Alan J
- Description
- D-Glucose improves memory in animals and humans and in subjects with memory pathologies. To date, the accepted conclusion drawn from animal research is that D-glucose improves memory via alterations in central cholinergic systems. However, recent evidence suggests that a sugar which does not cross the blood-brain barrier also facilitates memory (Talley, Arankowsky-Sandoval, McCarty, & Gold, 1999). The present study examined the effects of peripherally administered L-glucose, a stereoisomer of D-glucose, in male mice. Intraperitoneal administration of L-glucose (300 mg/kg) before testing enhanced place learning in the Morris water maze. Mice injected with L-glucose had significantly shorter escape latencies than mice injected with saline (1 ml/kg). Effects were observed on both reference memory and working memory tasks. L-Glucose did not facilitate performance on either task when it was simultaneously administered with cholinergic antagonists that are excluded from the central nervous system. Thus, simultaneous administration of either methyl-scopolamine (0.3 mg/kg), a peripherally acting muscarinic receptor blocker, or hexamethonium (1 mg/kg), a peripherally acting nicotinic receptor blocker, reversed the effect of L-glucose on memory. These findings suggest that the memory effects of L-glucose may be mediated by facilitated acetylcholine synthesis and/or release in the peripheral nervous system.
- Description
- 12 page(s)
- Subject Keyword
- cholinergic mechanisms
- Subject Keyword
- memory
- Subject Keyword
- glucose
- Subject Keyword
- L-glucose
- Subject Keyword
- peripheral effects
- Subject Keyword
- insulin
- Resource Type
- journal article
- Organisation
- Macquarie University. Dept. of Psychology
- Identifier
- http://hdl.handle.net/1959.14/8232
- Identifier
- ISSN:1095-9564
- Identifier
- mq-rm-2002015547
- Language
- eng
- Reviewed
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