Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/42516
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- Title
- Myosin binding protein-C : enigmatic regulator of cardiac contraction
- Related
- International journal of biochemistry and cell biology, Vol. 39, Issue 12, p.2161-2166
- DOI
- 10.1016/j.biocel.2006.12.008
- Publisher
- Elsevier
- Date
- 2007
- FoR/RFCD Code(s)
-
030403 Characterisation of Biological Macromolecules
030406 Proteins and Peptides
060199 Biochemistry and Cell Biology not elsewhere classified
- Author/Creator
- Oakley, Cecily E
- Author/Creator
- Chamoun, Jean
- Author/Creator
- Brown, Louise J
- Author/Creator
- Hambly, Brett D
- Description
- Myosin binding protein C (MyBPC) is a sarcomeric protein whose role in sarcomere structure and regulation of contraction is currently under investigation. It is a member of the immunoglobulin superfamily and is found in the C-zone of the A-band of the sarcomere. The elongated structure of MyBPC is composed of a series of immunoglobulin and fibronectin domains, with the C-terminal domains binding to the myosin thick filament and the N-terminal domains interacting with the myosin subfragment-2 (S2) neck region and possibly the actin thin filament. The functions of MyBPC are to stabilise the sarcomere structure and to regulate contraction. When phosphorylated near its N-terminus, MyBPC no longer binds myosin-S2, causing an increase in the ordering of the myosin heads, ATPase activity, Fmax and Ca²⁺ sensitivity of contraction. Mutations in MyBPC have been found to cause familial hypertrophic cardiomyopathy (FHC) and changes in MyBPC phosphorylation have been linked to cardiac ischaemia-reperfusion injury.
- Description
- 6 page(s)
- Subject Keyword
- 030403 Characterisation of Biological Macromolecules
- Subject Keyword
- 030406 Proteins and Peptides
- Subject Keyword
- 060199 Biochemistry and Cell Biology not elsewhere classified
- Subject Keyword
- myosin binding protein-C
- Subject Keyword
- hypertrophic cardiomyopathy
- Subject Keyword
- sarcomeric proteins
- Subject Keyword
- immunoglobulin superfamily
- Resource Type
- journal article
- Organisation
- Macquarie University. Dept. of Chemistry and Biomolecular Sciences
- Identifier
- http://hdl.handle.net/1959.14/42516
- Identifier
- ISSN:1357-2725
- Identifier
- mq-rm-2007001873
- Language
- eng
- Reviewed
