Molecular characterisation and expression of CD4 in two distantly related marsupials : the gray short-tailed opossum (Monodelphis domestica) and tammar wallaby (Macropus eugenii) | Macquarie University ResearchOnline

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Molecular characterisation and expression of CD4 in two distantly related marsupials : the gray short-tailed opossum (Monodelphis domestica) and tammar wallaby (Macropus eugenii)

Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/42160

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Title: Molecular characterisation and expression of CD4 in two distantly related marsupials : the gray short-tailed opossum (Monodelphis domestica) and tammar wallaby (Macropus eugenii)
Related: Molecular immunology, Vol. 44, Issue 15, p.3641-3652
DOI: 10.1016/j.molimm.2007.04.013
Publisher: Elsevier
Date: 2007
Author/Creator: Duncan, Louise G.
Author/Creator: Nair, Sham V
Author/Creator: Deane, Elizabeth M
Description: The gene and corresponding cDNA for CD4 in the gray short-tailed opossum, Monodelphis domestica, and the cDNA sequence for CD4 in the tammar wallaby, Macropus eugenii, have been characterised. The opossum CD4 homolog reveals conserved synteny, preserved genomic organisation and analogous structural arrangement to human and mouse CD4. Opossum and tammar CD4 exhibit typical eutherian CD4 features including the highly conserved p56lck binding motif in the cytoplasmic region and the invariant cysteine residues in extracellular domains 1 and 4. Interestingly, the marsupial CD4 sequences substitute a tryptophan for the first cysteine in domain 2 negating the formation of a disulphide bond as seen in other eutherian CD4 sequences except human and mouse. Overall the marsupial CD4 sequences share amino acid identity of 59% to each other and 37–41% with eutherian mammals. However, in contrast to eutherian homologs, the marsupial CD4 sequences were found to be truncated at the terminal end of the cytoplasmic tail. This is the first report confirming the presence of CD4 in a marsupial and describing its key features.
Description: 12 page(s)
Subject Keyword: marsupial
Subject Keyword: Monodelphis domestica
Subject Keyword: Macropus eugenii
Subject Keyword: CD4
Subject Keyword: T cells
Resource Type: journal article
Organisation: Macquarie University. Dept. of Biological Sciences

Identifier: http://hdl.handle.net/1959.14/42160
Identifier: ISSN:0161-5890
Identifier: mq-rm-2007002747
Language: eng
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