For many of the children who are blind and who also display features of Autism Spectrum Disorder (ASD) it is possible that their characteristics, while being representative of ASD, actually follow a different pathway to those children who have ASD and are sighted. It is proposed that these children should be viewed as having specific features rather than being a part of the collective of ASD. This article explores this issue by comparing the criteria for ASD with behaviours of both children who are sighted and those who are blind. Additionally, the diagnoses of blindness associated with neurological involvement and early medical complications are discussed. The effectiveness of intervention strategies and programmes is explored.