Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/25857
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- Title
- Human lens chemistry - UV filters and cataract
- Related
- European Chemistry Congress (1st : 2006) (27 - 31 August 2006 : Budapest, Hungary)
- Related
- 1st European chemistry congress : abstract book, p.227
- Related
- http://www.mke.org.hu/conferences/euchems/downloadfile.php?id=65
- Publisher
- Hungary : European Association for Chemical and Molecular Sciences
- Date
- 2006
- Author/Creator
- Mizdrak, Jasminka
- Author/Creator
- Hains, Peter G
- Author/Creator
- Truscott, Roger J. W
- Author/Creator
- Davies, Michael J
- Author/Creator
- Jamie, Joanne F
- Description
- The primate lens contains fluorescent tryptophan derived compounds known as UV filters. These absorb UV light and protect the lens from UV induced photo-damage. The major UV filters are 3-hydroxykynurenine O-Beta-D-glucoside, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-Beta-D-glucoside, kynurenine and 3-hydroxykynurenine. As the lens ages, a broad spectrum of molecular and biochemical changes occurs. We have shown that the UV filter compounds at physiological pH undergo spontaneous deamination, and bind to lens proteins and lens nucleophiles.(1,2) We have also demonstrated that kynurenine bound to lens proteins become highly susceptible to photo-oxidation in the presence of UV light and generates protein damage.(3) A greater understanding of the UV protective and photosensitising mechanisms of known human lens UV filters, and determination of as yet unidentified UV filters, is therefore required. The identification, synthesis and properties of human lens UV filters will be discussed. 1) Vazquez S., et al., J. Biol. Chem., 277, 4867-4873 (2002) 2) Hood B.D., et al., J. Biol. Chem., 274, 32547-32550 (1999) 3) Parker N.R., et al., Free Radical Biol. & Med., 37, 1479-1489 (2004)
- Description
- 1 page(s)
- Subject Keyword
- UV filter
- Subject Keyword
- cataract
- Subject Keyword
- human lens
- Resource Type
- conference paper abstract
- Organisation
- Macquarie University. Dept. of Chemistry and Biomolecular Sciences
- Identifier
- http://hdl.handle.net/1959.14/25857
- Identifier
- ISBN:9639319619
- Identifier
- mq-rm-2006003389
- Language
- eng
