Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

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Title: Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma
Related: Nature genetics, Vol. 46, No. 11, (2014), p.1233-1238
DOI: 10.1038/ng.3105
Publisher: Nature Publishing Group
Date: 2014
Author/Creator: Cerhan, James R
Author/Creator: Berndt, Sonja I
Author/Creator: Nieters, Alexandra
Author/Creator: Laden, Francine
Author/Creator: Giovannucci, Edward
Author/Creator: Kraft, Peter
Author/Creator: Huang, Jinyan
Author/Creator: Ma, Baoshan
Author/Creator: Ye, Yuanqing
Author/Creator: Chiu, Brian C. H
Author/Creator: Sampson, Joshua
Author/Creator: Liang, Liming
Author/Creator: Park, Ju-Hyun
Author/Creator: Cox, David
Author/Creator: Chung, Charles C
Author/Creator: Weisenburger, Dennis D
Author/Creator: Chatterjee, Nilanjan
Author/Creator: Fraumeni Jr., Joseph F
Author/Creator: Slager, Susan L
Author/Creator: Wu, Xifeng
Author/Creator: de Sanjose, Silvia
Author/Creator: Smedby, Karin E
Author/Creator: Salles, Gilles
Author/Creator: Skibola, Christine F
Author/Creator: Burdett, Laurie
Author/Creator: Rothman, Nathaniel
Author/Creator: Chanock, Stephen J
Author/Creator: Monnereau, Alain
Author/Creator: Flowers, Christopher R
Author/Creator: De Roos, Anneclaire J
Author/Creator: Brooks-Wilson, Angela R
Author/Creator: Lan, Qing
Author/Creator: Severi, Gianluca
Author/Creator: Melbye, Mads
Author/Creator: Vijai, Joseph
Author/Creator: Gu, Jian
Author/Creator: Jackson, Rebecca D
Author/Creator: Kane, Eleanor
Author/Creator: Teras, Lauren R
Author/Creator: Purdue, Mark P
Author/Creator: Vajdic, Claire M
Author/Creator: Spinelli, John J
Author/Creator: Giles, Graham G
Author/Creator: Albanes, Demetrius
Author/Creator: Kelly, Rachel S
Author/Creator: Ghesquieres, Hervé
Author/Creator: Zucca, Mariagrazia
Author/Creator: Bertrand, Kimberly A
Author/Creator: Zeleniuch-Jacquotte, Anne
Author/Creator: Lawrence, Charles
Author/Creator: Hutchinson, Amy
Author/Creator: Zhi, Degui
Author/Creator: Habermann, Thomas M
Author/Creator: Link, Brian K
Author/Creator: Novak, Anne J
Author/Creator: Dogan, Ahmet
Author/Creator: McKay, James
Author/Creator: Asmann, Yan W
Author/Creator: Liebow, Mark
Author/Creator: Thompson, Carrie A
Author/Creator: Ansell, Stephen M
Author/Creator: Witzig, Thomas E
Author/Creator: Weiner, George J
Author/Creator: Veron, Amelie S
Author/Creator: Zelenika, Diana
Author/Creator: Tilly, Hervé
Author/Creator: Haioun, Corinne
Author/Creator: Wang, Sophia S
Author/Creator: Molina, Thierry Jo
Author/Creator: Hjalgrim, Henrik
Author/Creator: Glimelius, Bengt
Author/Creator: Adami, Hans-Olov
Author/Creator: Bracci, Paige M
Author/Creator: Riby, Jacques
Author/Creator: Smith, Martyn T
Author/Creator: Holly, Elizabeth A
Author/Creator: Cozen, Wendy
Author/Creator: Hartge, Patricia
Author/Creator: Wang, Zhaoming
Author/Creator: Morton, Lindsay M
Author/Creator: Severson, Richard K
Author/Creator: Tinker, Lesley F
Author/Creator: North, Kari E
Author/Creator: Becker, Nikolaus
Author/Creator: Benavente, Yolanda
Author/Creator: Boffetta, Paolo
Author/Creator: Brennan, Paul
Author/Creator: Foretova, Lenka
Author/Creator: Maynadie, Marc
Author/Creator: Yeager, Meredith
Author/Creator: Staines, Anthony
Author/Creator: Lightfoot, Tracy
Author/Creator: Crouch, Simon
Author/Creator: Smith, Alex
Author/Creator: Roman, Eve
Author/Creator: Diver, W. Ryan
Author/Creator: Offit, Kenneth
Author/Creator: Zelenetz, Andrew
Author/Creator: Klein, Robert J
Author/Creator: Villano, Danylo J
Author/Creator: Conde, Lucia
Author/Creator: Zheng, Tongzhang
Author/Creator: Zhang, Yawei
Author/Creator: Holford, Theodore R
Author/Creator: Kricker, Anne
Author/Creator: Turner, Jenny
Author/Creator: Southey, Melissa C
Author/Creator: Clavel, Jacqueline
Author/Creator: Virtamo, Jarmo
Author/Creator: Weinstein, Stephanie
Author/Creator: Riboli, Elio
Author/Creator: de Bakker, Paul I. W
Author/Creator: Vineis, Paolo
Author/Creator: Kaaks, Rudolph
Author/Creator: Trichopoulos, Dimitrios
Author/Creator: Vermeulen, Roel C. H
Author/Creator: Boeing, Heiner
Author/Creator: Tjonneland, Anne
Author/Creator: Angelucci, Emanuele
Author/Creator: Di Lollo, Simonetta
Author/Creator: Rais, Marco
Author/Creator: Birmann, Brenda M
Description: Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 x 10 ⁻²¹), rs2523607 at 6p21.33 (HLA-B; P = 2.40 x 10 ⁻¹⁰), rs79480871 at 2p23.3 (NCOA1; P = 4.23 x 10 ⁻⁸) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 x 10 ⁻¹³ and 3.63 x 10 ⁻¹¹, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.
Description: 6 page(s)
Resource Type: journal article
Organisation: Macquarie University. Australian School of Advanced Medicine

Identifier: http://hdl.handle.net/1959.14/325375
Identifier: mq:35898
Identifier: ISSN:1061-4036
Identifier: mq-rm-2013008574
Identifier: mq_res-ext-2-s2.0-84908886283
Language: eng
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