Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/305231

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Title: Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
Related: Nature genetics, Vol. 41, No. 10, (2009), p.1116-1121
DOI: 10.1038/ng.450
Publisher: Nature Publishing Group
Date: 2009
Author/Creator: Eeles, Rosalind A
Author/Creator: Kote-Jarai, Zsofia
Author/Creator: Schleutker, Johanna
Author/Creator: Easton, Douglas F
Author/Creator: Bollina, Prasad
Author/Creator: Bonnington, Sue
Author/Creator: Cooper, Debbie
Author/Creator: Doble, Andrew
Author/Creator: Doherty, Alan
Author/Creator: Durkan, Garrett
Author/Creator: Elliott, Emma
Author/Creator: Gillatt, David
Author/Creator: Herbert, Pippa
Author/Creator: Hamdy, Freddie C
Author/Creator: Holding, Peter
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Author/Creator: Koopmeiners, Joseph S
Author/Creator: Karyadi, Danielle M
Author/Creator: Kwon, Erika M
Author/Creator: Stern, Mariana C
Author/Creator: Corral, Roman
Author/Creator: Joshi, Amit D
Author/Creator: Shahabi, Ahva
Author/Creator: McDonnell, Shannon K
Author/Creator: Sellers, Thomas A
Author/Creator: Henderson, Brian E
Author/Creator: Pow-Sang, Julio
Author/Creator: Chambers, Suzanne
Author/Creator: Aitken, Joanne
Author/Creator: Gardiner, R. A. (Frank)
Author/Creator: Batra, Jyotsna
Author/Creator: Kedda, Mary Anne
Author/Creator: Lose, Felicity
Author/Creator: Polanowski, Andrea
Author/Creator: Patterson, Briony
Author/Creator: Serth, Jürgen
Author/Creator: Haiman, Christopher A
Author/Creator: Meyer, Andreas
Author/Creator: Luedeke, Manuel
Author/Creator: Stefflova, Klara
Author/Creator: Ray, Anna M
Author/Creator: Lange, Ethan M
Author/Creator: Farnham, Jim
Author/Creator: Khan, Humera
Author/Creator: Slavov, Chavdar
Author/Creator: Mitkova, Atanaska
Author/Creator: Cao, Guangwen
Description: Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10⁻⁸ to P = 2.7 x 10⁻³³).
Description: 6 page(s)
Subject Keyword: 110300 Clinical Sciences
Subject Keyword: 111200 Oncology and Carcinogenesis
Resource Type: journal article
Organisation: Macquarie University. Australian School of Advanced Medicine

Identifier: http://hdl.handle.net/1959.14/305231
Identifier: mq:33213
Identifier: ISSN:1061-4036
Identifier: mq-rm-2013005406
Identifier: mq_res-ext-2-s2.0-70349545839
Language: eng
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