Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/274876

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Title: Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
Related: Nature genetics, Vol. 45, No. 8, (2013), p.868-876
DOI: 10.1038/ng.2652
Publisher: Nature Publishing Group
Date: 2013
Author/Creator: Berndt, Sonja I
Author/Creator: Skibola, Christine F
Author/Creator: Lan, Qing
Author/Creator: Laden, Francine
Author/Creator: Giovannucci, Edward
Author/Creator: Kraft, Peter
Author/Creator: Kricker, Anne
Author/Creator: Turner, Jenny
Author/Creator: Vajdic, Claire M
Author/Creator: Ennas, Maria Grazia
Author/Creator: Ferri, Giovanni M
Author/Creator: Miligi, Lucia
Author/Creator: Liang, Liming
Author/Creator: Teras, Lauren R
Author/Creator: Sampson, Joshua
Author/Creator: Crouch, Simon
Author/Creator: Park, Ju-Hyun
Author/Creator: North, Kari E
Author/Creator: Cox, Angela
Author/Creator: Snowden, John A
Author/Creator: Wright, Josh
Author/Creator: Carracedo, Angel
Author/Creator: Lopez-Otin, Carlos
Author/Creator: Bea, Silvia
Author/Creator: Chatterjee, Nilanjan
Author/Creator: Salaverria, Itziar
Author/Creator: Martin-Garcia, David
Author/Creator: Campo, Elias
Author/Creator: Fraumeni Jr, Joseph F
Author/Creator: de Sanjose, Silvia
Author/Creator: Hjalgrim, Henrik
Author/Creator: Cerhan, James R
Author/Creator: Chanock, Stephen J
Author/Creator: Rothman, Nathaniel
Author/Creator: Slager, Susan L
Author/Creator: Chung, Charles C
Author/Creator: Yeager, Meredith
Author/Creator: Brooks-Wilson, Angela R
Author/Creator: Hartge, Patricia
Author/Creator: Purdue, Mark P
Author/Creator: Birmann, Brenda M
Author/Creator: Armstrong, Bruce K
Author/Creator: Joseph, Vijai
Author/Creator: Cocco, Pierluigi
Author/Creator: Zhang, Yawei
Author/Creator: Severi, Gianluca
Author/Creator: Zeleniuch-Jacquotte, Anne
Author/Creator: Lawrence, Charles
Author/Creator: Burdette, Laurie
Author/Creator: Yuenger, Jeffrey
Author/Creator: Hutchinson, Amy
Author/Creator: Jacobs, Kevin B
Author/Creator: Call, Timothy G
Author/Creator: Camp, Nicola J
Author/Creator: Shanafelt, Tait D
Author/Creator: Novak, Anne J
Author/Creator: Kay, Neil E
Author/Creator: Liebow, Mark
Author/Creator: Wang, Alice H
Author/Creator: Smedby, Karin E
Author/Creator: Adami, Hans-Olov
Author/Creator: Melbye, Mads
Author/Creator: Glimelius, Bengt
Author/Creator: Chang, Ellen T
Author/Creator: Nieters, Alexandra
Author/Creator: Glenn, Martha
Author/Creator: Curtin, Karen
Author/Creator: Cannon-Albright, Lisa A
Author/Creator: Jones, Brandt
Author/Creator: Diver, W. Ryan
Author/Creator: Link, Brian K
Author/Creator: Weiner, George J
Author/Creator: Conde, Lucia
Author/Creator: Bracci, Paige M
Author/Creator: Riby, Jacques
Author/Creator: Wang, Zhaoming
Author/Creator: Holly, Elizabeth A
Author/Creator: Smith, Martyn T
Author/Creator: Jackson, Rebecca D
Author/Creator: Tinker, Lesley F
Author/Creator: Benavente, Yolanda
Author/Creator: Becker, Nikolaus
Author/Creator: Boffetta, Paolo
Author/Creator: Brennan, Paul
Author/Creator: Foretova, Lenka
Author/Creator: Maynadie, Marc
Author/Creator: Cozen, Wendy
Author/Creator: McKay, James
Author/Creator: Staines, Anthony
Author/Creator: Rabe, Kari G
Author/Creator: Achenbach, Sara J
Author/Creator: Vachon, Celine M
Author/Creator: Goldin, Lynn R
Author/Creator: Strom, Sara S
Author/Creator: Lanasa, Mark C
Author/Creator: Spector, Logan G
Author/Creator: Leis, Jose F
Author/Creator: Monnereau, Alain
Author/Creator: Cunningham, Julie M
Author/Creator: Weinberg, J. Brice
Author/Creator: Morrison, Vicki A
Author/Creator: Caporaso, Neil E
Author/Creator: Norman, Aaron D
Author/Creator: Linet, Martha S
Author/Creator: De Roos, Anneclaire J
Author/Creator: Morton, Lindsay M
Author/Creator: Severson, Richard K
Author/Creator: Riboli, Elio
Author/Creator: Wang, Sophia S
Author/Creator: Vineis, Paolo
Author/Creator: Kaaks, Rudolph
Author/Creator: Trichopoulos, Dimitrios
Author/Creator: Masala, Giovanna
Author/Creator: Weiderpass, Elisabete
Author/Creator: Chirlaque, Maria-Dolores
Author/Creator: Vermeulen, Roel C. H
Author/Creator: Travis, Ruth C
Author/Creator: Giles, Graham G
Author/Creator: Albanes, Demetrius
Author/Creator: Kelly, Rachel S
Author/Creator: Virtamo, Jarmo
Author/Creator: Weinstein, Stephanie
Author/Creator: Clavel, Jacqueline
Author/Creator: Zheng, Tongzhang
Author/Creator: Holford, Theodore R
Author/Creator: Offit, Kenneth
Author/Creator: Zelenetz, Andrew
Author/Creator: Klein, Robert J
Author/Creator: Spinelli, John J
Author/Creator: Bertrand, Kimberly A
Description: Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 x 10⁻¹⁴), 18q21.33 (BCL2, P = 7.76 x 10⁻11), 11p15.5 (C11orf21, P = 2.15 x 10⁻¹⁰), 4q25 (LEF1, P = 4.24 x 10⁻¹⁰), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 x 10⁻⁹), 9p21.3 (CDKN2B-AS1, P = 1.27 x 10⁻⁸), 18q21.32 (PMAIP1, P = 2.51 x 10⁻⁸), 15q15.1 (BMF, P = 2.71 x 10⁻¹⁰ⁱ) and 2p22.2 (QPCT, P = 1.68 x 10⁻⁸), as well as an independent signal at an established locus (2q13, ACOXL, P = 2.08 x 10⁻¹⁸). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P = 5.40 x 10⁻⁸) and 5p15.33 (TERT, P = 1.92 x 10⁻⁷). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism.
Description: 9 page(s)
Subject Keyword: 111200 Oncology and Carcinogenesis
Resource Type: journal article
Organisation: Macquarie University. Australian School of Advanced Medicine

Identifier: http://hdl.handle.net/1959.14/274876
Identifier: mq:29147
Identifier: ISSN:1061-4036
Identifier: mq-rm-2013000348
Identifier: mq_res-ext-2-s2.0-84881023533
Language: eng
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