Reduced T helper and B lymphocytes in Parkinson's disease | Macquarie University ResearchOnline

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Title: Reduced T helper and B lymphocytes in Parkinson's disease
Related: Journal of neuroimmunology, Vol. 252, Issue 1-2, (2012), p.95-99
DOI: 10.1016/j.jneuroim.2012.07.015
Publisher: Elsevier
Date: 2012
Author/Creator: Stevens, Claire H
Author/Creator: Rowe, Dominic
Author/Creator: Morel-Kopp, Marie-Christine
Author/Creator: Orr, Carolyn
Author/Creator: Russell, Tonia
Author/Creator: Ranola, Madelaine
Author/Creator: Ward, Christopher
Author/Creator: Halliday, Glenda M
Description: Gene association with HLA suggests involvement of immune mediated mechanisms in the pathogenesis of Parkinson's disease (PD). Only a small number of studies have found differences between circulating leukocyte populations in PD patients compared to controls, with conflicting results. To clarify whether there is a circulating leukocyte PD phenotype, we assessed the numbers of T, B and natural killer cells, and monocytes and found a small reduction (15-25%) in CD4 + T and CD19 + B cells in PD. These findings suggest some compromise in immune cells in PD and have potential implications for immune function and the progression of PD.
Description: 5 page(s)
Subject Keyword: B lymphocytes
Subject Keyword: Parkinson's disease
Subject Keyword: T lymphocytes
Resource Type: journal article
Organisation: Macquarie University. Australian School of Advanced Medicine

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