Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/191247
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- Title
- Refraction-compensated motion tracking of unrestrained small animals in positron emission tomography
- Related
- Medical image analysis, Vol. 16, No. 6, (2012), p.1317-1328
- DOI
- 10.1016/j.media.2012.04.005
- Publisher
- Elsevier
- Date
- 2012
- Author/Creator
- Kyme, Andre
- Author/Creator
- Meikle, Steven
- Author/Creator
- Baldock, Clive
- Author/Creator
- Fulton, Roger
- Description
- Motion-compensated radiotracer imaging of fully conscious rodents represents an important paradigm shift for preclinical investigations. In such studies, if motion tracking is performed through a transparent enclosure containing the awake animal, light refraction at the interface will introduce errors in stereo pose estimation. We have performed a thorough investigation of how this impacts the accuracy of pose estimates and the resulting motion correction, and developed an efficient method to predict and correct for refraction-based error. The refraction model underlying this study was validated using a state-of-the-art motion tracking system. Refraction-based error was shown to be dependent on tracking marker size, working distance, and interface thickness and tilt. Correcting for refraction error improved the spatial resolution and quantitative accuracy of motion-corrected positron emission tomography images. Since the methods are general, they may also be useful in other contexts where data are corrupted by refraction effects.
- Description
- 12 page(s)
- Subject Keyword
- Positron emission tomography
- Subject Keyword
- Refraction
- Subject Keyword
- Stereo motion tracking
- Subject Keyword
- Triangulation
- Resource Type
- journal article
- Organisation
- Macquarie University. Faculty of Science
- Identifier
- http://hdl.handle.net/1959.14/191247
- Identifier
- ISSN:1361-8415
- Identifier
- mq_res-ext-2-s2.0-84866136516
- Language
- eng
- Reviewed
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