Expression and sequence analyses of serum amyloid A in the Syrian hamster | Macquarie University ResearchOnline

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Title: Expression and sequence analyses of serum amyloid A in the Syrian hamster
Related: Biochemistry, Vol. 28, Issue 11, (1989), p.4785-4790
DOI: 10.1021/bi00437a040
Publisher: American Chemical Society
Date: 1989
Author/Creator: Webb, C. F
Author/Creator: Tucker, P. W
Author/Creator: Dowton, S. Bruce
Description: Reactive amyloidosis occurs during chronic inflammation and involves deposition of amyloid A (AA) fibrils in many organs. Amyloid A is derived by proteolysis from serum amyloid A component (SAA), a major acute-phase reactant in many species. Since spontaneous amyloidosis occurs commonly in Syrian hamsters, we have studied the structure and expression of SAA genes during inflammation in these animals. Two cDNA clones and one genomic clone were sequenced, suggesting that Syrian hamster SAA is encoded by at least two genes. Hepatic mRNA analyses showed that SAA was inducible in many hamster organs during acute inflammation. These studies also demonstrated that SAA mRNA for one isotype is maximally expressed at a site of local tissue damage.
Description: 6 page(s)
Resource Type: journal article
Organisation: Macquarie University. Office of the Vice-Chancellor

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