Introduction. The main aims of the study were the translation into Italian, and validation subsequently of the Addenbrooke's Cognitive Examination Revised (ACE-R), and the evaluation of its usefulness in discriminating cognitively normal subjects from patients with mild dementia. Methods. The ACE-R was translated and adapted into Italian. The Italian ACE-R was administrated to a group of 179 elderly subjects (72 cognitively intact and 107 subjects with mild dementia, mean age 75.4 years ± 6.4). The group was stratified in two sub-samples according to age, i.e. young-old (< 75 years) and old-old (≥ 75 years), in order to evaluate test's sensitivity and specificity in detecting dementia among elderly of different age. Results. The reliability of the Italian ACE-R was excellent (alpha coefficient = 0.85). Two different cut-offs were identified for young-old (cut-off 79; sensitivity 90% and specificity 80%); and old-old subjects (cut-off 60; sensitivity 82% and specificity 100%). Discussion. The Italian ACE-R is a valid screening tool to detect dementia. This is true especially among the old-old individuals, the fastest growing age group and the one at the highest risk of dementia in western countries.
Previously published as Pigliautile M, Ricci M, Mioshi E, Ercolani S, Mangialasche F, Monastero R, Croce MF, Federici S, Mecocci P: Validation Study of the Italian Addenbrooke’s Cognitive Examination Revised in a Young-Old and Old-Old Population. Dement Geriatr Cogn Disord 2011;32:301-307 (DOI: 10.1159/000334657).