Hypoplastic left heart syndrome (HLHS) is one kind of congenital heart diseases of newborn. The surgeries for HLHS have to be carried out at very early stage. However, currently there are no quantitative standard to evaluate and predict the outcome of the therapy. In this study, computational fluid dynamics (CFD) is introduced simulate the hemodynamics after Norwood surgery; a first stage surgery for HLHS. Blood flows derived from Echocardiography measurements were used as boundary conditions for pulsatile calculation. The circulations of blood flows were observed and the flow distribution in each vessel is estimated. Energy losses (EL), local pressure, and wall shear stress (WSS) in anastomosis were analyzed to estimate the result of HLHS treatment. The results indicate that pulsatile simulation is essential to quantitatively evaluate the quality of HLHS operation, and the method of computational hemodynamics analysis could be applied into the process of the operations for surgical optimization.