Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/180587
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- Title
- Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity
- Related
- Respiratory physiology and neurobiology, Vol. 168, Issue 1-2, (2009), p.59-68
- DOI
- 10.1016/j.resp.2009.02.001
- Publisher
- Elsevier BV
- Date
- 2009
- FoR/RFCD Code(s)
-
111600 Medical Physiology
110200 Cardiovascular Medicine and Haematology
- Author/Creator
- Guyenet, Patrice G
- Author/Creator
- Bayliss, Douglas A
- Author/Creator
- Stornetta, Ruth L
- Author/Creator
- Fortuna, Michal G
- Author/Creator
- Abbott, Stephen B. G
- Author/Creator
- Depuy, Seth D
- Description
- Breathing automaticity and CO₄ regulation are inseparable neural processes. The retrotrapezoid nucleus (RTN), a group of glutamatergic neurons that express the transcription factor Phox2b, may be a crucial nodal point through which breathing automaticity is regulated to maintain CO₄ constant. This review updates the analysis presented in prior publications. Additional evidence that RTN neurons have central respiratory chemoreceptor properties is presented, but this is only one of many factors that determine their activity. The RTN is also regulated by powerful inputs from the carotid bodies and, at least in the adult, by many other synaptic inputs. We also analyze how RTN neurons may control the activity of the downstream central respiratory pattern generator. Specifically, we review the evidence which suggests that RTN neurons (a) innervate the entire ventral respiratory column and (b) control both inspiration and expiration. Finally, we argue that the RTN neurons are the adult form of the parafacial respiratory group in neonate rats.
- Description
- 10 page(s)
- Subject Keyword
- 111600 Medical Physiology
- Subject Keyword
- 110200 Cardiovascular Medicine and Haematology
- Subject Keyword
- Central chemoreceptors
- Subject Keyword
- Breathing
- Subject Keyword
- Phox2b
- Subject Keyword
- Retrotrapezoid nucleus
- Subject Keyword
- Parafacial respiratory group
- Resource Type
- journal article
- Organisation
- Macquarie University. Australian School of Advanced Medicine
- Identifier
- http://hdl.handle.net/1959.14/180587
- Identifier
- ISSN:1569-9048
- Identifier
- mq-rm-2009003877
- Language
- eng
- Reviewed
