Galanin microinjection into the PreBötzinger or the Bötzinger Complex terminates central inspiratory activity and reduces responses to hypoxia and hypercapnia in rat | Macquarie University ResearchOnline

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Galanin microinjection into the PreBötzinger or the Bötzinger Complex terminates central inspiratory activity and reduces responses to hypoxia and hypercapnia in rat

Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/180374

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Title: Galanin microinjection into the PreBötzinger or the Bötzinger Complex terminates central inspiratory activity and reduces responses to hypoxia and hypercapnia in rat
Related: Respiratory physiology and neurobiology, Vol. 167, Issue 3, (2009), p.299-306
DOI: 10.1016/j.resp.2009.06.003
Publisher: Elsevier
Date: 2009
FoR/RFCD Code(s): 111600 Medical Physiology 110200 Cardiovascular Medicine and Haematology
Author/Creator: Abbott, Stephen B. G
Author/Creator: Burke, Peter G. R
Author/Creator: Pilowsky, Paul M
Description: Respiratory rhythm is generated and shaped by the synaptic interaction of neurons in the Bötzinger Complex (BötC) and PreBötzinger Complex (PreBötC) located in the ventral respiratory column of the medulla. Metabotropic receptors are important modulators of fast neurotransmission in the generation and shaping of respiratory rhythm. Microinjection of the neuropeptide galanin (1 mM, 50 nL, 50 pmol) into functionally identified BötC or PreBötC in urethane anesthetized, mechanically ventilated and vagotomized rats caused severe dysrhythmia or persistent apnea. In the BötC and PreBötC, galanin reduced the ventilatory response to hypercapnia (5% CO₂) by 21% (P < 0.001) and 38% (P < 0.01) respectively. In the BötC and PreBötC, galanin reduced the ventilatory response to hypoxia (10% O₂) by 15% (P < 0.05) and 23% (P < 0.01) respectively. These results indicate that microinjection of galanin into the BötC or PreBötC depresses a neural substrate required for the generation of respiratory motor output and reflex responses to hypercapnea and hypoxia.
Description: 8 page(s)
Subject Keyword: 111600 Medical Physiology
Subject Keyword: 110200 Cardiovascular Medicine and Haematology
Subject Keyword: Galanin
Subject Keyword: PreBötzinger Complex
Subject Keyword: Hypercapnia
Subject Keyword: Neuropeptide
Subject Keyword: Ventral respiratory complex
Resource Type: journal article
Organisation: Macquarie University. Australian School of Advanced Medicine

Identifier: http://hdl.handle.net/1959.14/180374
Identifier: ISSN:1569-9048
Identifier: mq-rm-2009003329
Language: eng
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