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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/176946
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- Title
- Non-specific internalization of laser ablated pure gold nanoparticles in pancreatic tumor cell
- Related
- Colloids and surfaces. B : Biointerfaces, Vol. 92, (2012), p.190-195
- DOI
- 10.1016/j.colsurfb.2011.11.046
- Publisher
- Elsevier
- Date
- 2012
- Author/Creator
- Sobhan, M. A
- Author/Creator
- Sreenivasan, V. K. A
- Author/Creator
- Withford, M. J
- Author/Creator
- Goldys, E. M
- Description
- We investigate the intracellular uptake of 7.3. nm, 21.2. nm and 31.3. nm average size pure colloidal gold nanoparticles synthesized using femtosecond laser ablation technique in pure water. Dark-field imaging, transmission electron microscopy (TEM) and scanning electron microscopy (SEM) was used to assess the uptake of these pure gold nanoparticles in the pancreatic tumor cell line. We show that these ligand-free gold nanoparticles are non-toxic to these cells. The nanoparticles and cell images indicated that unmodified gold nanoparticles interacted with the cells, despite negative surface charge on both the cells and the nanoparticles. We also demonstrate that the uptake of the gold nanoparticles is size-dependent.
- Description
- 6 page(s)
- Subject Keyword
- 111200 Oncology and Carcinogenesis
- Subject Keyword
- Electron microscopy
- Subject Keyword
- Gold nanoparticles
- Subject Keyword
- Laser ablation
- Subject Keyword
- Pancreatic tumor cells
- Resource Type
- journal article
- Organisation
- Macquarie University. MQ BioFocus Research Centre
- Organisation
- Macquarie University. Centre for Ultrahigh-bandwidth Devices for Optical Systems (CUDOS)
- Identifier
- http://hdl.handle.net/1959.14/176946
- Identifier
- mq:20317
- Identifier
- ISSN:0927-7765
- Identifier
- mq-rm-2011007343
- Identifier
- mq_res-ext-2-s2.0-84856109467
- Language
- eng
- Reviewed
Macquarie University ResearchOnline
