Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/172761
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- Title
- Total synthesis of homogeneous antifreeze glycopeptides and glycoproteins
- Related
- Angewandte Chemie : international edition, Vol. 51, No. 15, (2012), p.3606-3610
- DOI
- 10.1002/anie.201108682
- Publisher
- Wiley-Blackwell
- Date
- 2012
- Author/Creator
- Wilkinson, Brendan L
- Author/Creator
- Stone, Robin S
- Author/Creator
- Capicciotti, Chantelle J
- Author/Creator
- Thaysen-Andersen, Morten
- Author/Creator
- Matthews, Jacqueline M
- Author/Creator
- Packer, Nicolle H
- Author/Creator
- Ben, Robert N
- Author/Creator
- Payne, Richard J
- Description
- Don't freeze! A native chemical ligation-desulfurization strategy has been employed for the convergent synthesis of a library of defined antifreeze glycopeptides and glycoproteins (AFGPs) ranging in size from 1.2 to 19.5 kDa (see picture). These AFGPs possessed the secondary structure of a polyproline type II helix and exhibited significant ice recrystallization inhibition and thermal hysteresis activity.
- Description
- 5 page(s)
- Subject Keyword
- antifreeze proteins
- Subject Keyword
- chemical ligation
- Subject Keyword
- glycopeptides
- Subject Keyword
- glycoproteins
- Subject Keyword
- thermal hysteresis
- Resource Type
- journal article
- Organisation
- Macquarie University. Biomolecular Frontiers Research Centre
- Identifier
- http://hdl.handle.net/1959.14/172761
- Identifier
- ISSN:1433-7851
- Identifier
- mq_res-ext-2-s2.0-84859540284
- Language
- eng
- Reviewed
