Mapping of the Plasmodium chabaudi resistance locus char2 | Macquarie University ResearchOnline

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Title: Mapping of the Plasmodium chabaudi resistance locus char2
Related: Infection and immunity, Vol. 74, Issue 10, (2006), p.5814-5819
DOI: 10.1128/IAI.01690-05
Publisher: American Society for Microbiology
Date: 2006
Author/Creator: Lin, Enmoore
Author/Creator: Pappenfuss, Tony
Author/Creator: Tan, Rachel B
Author/Creator: Senyschyn, Danielle
Author/Creator: Bahlo, Melanie
Author/Creator: Speed, Terence P
Author/Creator: Foote, Simon J
Description: Animals congenic for the char2 host response locus to the murine malarial parasite Plasmodium chabaudi have been bred, and they demonstrated a phenotypic difference from the parental lines. These congenic lines have been crossed back to the parental line to generate recombinants across the congenic intervals. The recombinants were inbred, and the subcongenic intervals were fixed. These lines were then challenged with parasites and assessed as being either resistant or susceptible. From the analysis of many subcongenic lines, it has become obvious that there are at least two loci underlying the char2 locus and that both of these mediate resistance when the haplotype derives from the resistant C57BL/6 strain.
Description: 6 page(s)
Resource Type: journal article
Organisation: Macquarie University. Australian School of Advanced Medicine

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