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Tethered bilayer membrane sensors with small transmembrane peptide ion channels - recent developments, future reserch and potential applications

Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/169614

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Title: Tethered bilayer membrane sensors with small transmembrane peptide ion channels - recent developments, future reserch and potential applications
Related: Ottova-Leitmannova, A.. Advances in planar lipid bilayers and liposomes : Vol. 2, p.49-76
DOI: 10.1016/S1554-4516(05)02002-8
Publisher: San Diego USA : Elsevier
Date: 2005
FoR/RFCD Code(s): 030500 Organic Chemistry
Author/Creator: Yin, Ping
Description: This chapter covers the chemistry and experimental approach for studying tethered bilayernext term lipid previous termmembranesnext term (tBLM) for incorporating the previous termsmall peptide transmembrane ion channelnext term alamethicin. It describes the chemical components developed by AMBRI and methods for optimizing the tBLM containing alamethicin in order to construct stable and sensitive previous termsensors. The sensornext term containing alamethicin previous termchannelsnext term was then probed with amiloride and its analogues in the μM concentration range. The potency of amiloride and analogues as previous termchannelnext term blocker is rated against their molecular structure. Current research activities in related areas are also reviewed. The potential applications are studying “signature sequences” of large menbrane previous termchannelnext term proteins, previous termsmallnext term molecule sensing and biodiscovery.
Description: 28 page(s)
Subject Keyword: 030500 Organic Chemistry
Resource Type: book chapter
Organisation: Macquarie University. Dept. of Chemistry and Biomolecular Sciences

Identifier: http://hdl.handle.net/1959.14/169614
Identifier: ISBN:9780123694539
Identifier: ISSN:1554-4516
Identifier: mq-rm-2005000673
Language: eng

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