Mechanistic investigations of multidentate organocatalyst-promoted counterion catalysis for fast and enantioselective aza-Morita-Baylis-Hillman reactions at ambient temperature | Macquarie University ResearchOnline

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Title: Mechanistic investigations of multidentate organocatalyst-promoted counterion catalysis for fast and enantioselective aza-Morita-Baylis-Hillman reactions at ambient temperature
Related: Organic and biomolecular chemistry, Vol. 8, No. 19, (2010), p.4400-4407
DOI: 10.1039/c0ob00069h
Publisher: United Kingdom : Royal Society of Chemistry
Date: 2010
FoR/RFCD Code(s): 030500 Organic Chemistry 030400 Medicinal and Biomolecular Chemistry
Author/Creator: Anstiss, Christopher
Author/Creator: Garnier, Jean-Marc
Author/Creator: Liu, Fei
Description: Kinetic experiments were performed on the catalytic cycle of a trifunctional organocatalyst-promoted counterion catalysis of asymmetric aza-Morita–Baylis–Hillman reactions. The catalysis was found to be first order in the trifunctional catalyst with the Michael addition as the rate-limiting step. Temperature variation changed the rate of catalysis but not the enantioselectivity of the reaction.
Description: 8 page(s)
Subject Keyword: 030500 Organic Chemistry
Subject Keyword: 030400 Medicinal and Biomolecular Chemistry
Resource Type: journal article
Organisation: Macquarie University. Dept. of Chemistry and Biomolecular Sciences
Organisation: Macquarie University. Dept. of Biological Sciences

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