Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/143784
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- Title
- Proflavine derivatives as fluorescent imaging agents of amyloid deposits
- Related
- Bioorganic and medicinal chemistry letters, Vol. 21, No. 8, (2011), p.2203-2206
- DOI
- 10.1016/j.bmcl.2011.03.010
- Publisher
- Elsevier
- Date
- 2011
- Author/Creator
- Garin, Dominique
- Author/Creator
- Oukhatar, Fatima
- Author/Creator
- Mahon, Andrew B
- Author/Creator
- Try, Andrew C
- Author/Creator
- Dubois-Dauphin, Michel
- Author/Creator
- Laferla, Frank M
- Author/Creator
- Demeunynck, Martine
- Author/Creator
- Sallanon, Marcelle Moulin
- Author/Creator
- Chierici, Sabine
- Description
- A series of proflavine derivatives for use to further image Aβ amyloid deposits were synthesized and characterized. Aged 3xTg-AD (23 months old) mice hippocampus sections incubated with these derivatives revealed preferential labeling of amyloid plaques. Furthermore an in vitro binding study showed an inhibitory effect, although moderate, of these compounds on Aβ40 fibril formation. This study highlights the potential of proflavine as a molecular scaffold for designing new Aβ imaging agents, its native fluorescence allowing in vitro neuropathological staining in AD damaged brain sections.
- Description
- 4 page(s)
- Subject Keyword
- Amyloid deposits imaging
- Subject Keyword
- Click chemistry
- Subject Keyword
- Fluorescent markers
- Subject Keyword
- Proflavine
- Resource Type
- journal article
- Organisation
- Macquarie University. Dept. of Chemistry and Biomolecular Sciences
- Identifier
- http://hdl.handle.net/1959.14/143784
- Identifier
- ISSN:0960-894X
- Identifier
- mq_res-ext-2-s2.0-79953290815
- Language
- eng
- Reviewed
