The integration of regional infrastructure is essential for the economic wellbeing of nations, including developing countries. This project is particularly concerned with addressing regional port-to-port integration in the South American c.ontext. Towards this goal of integration, this paper proposes an initial interdisciplinary theoretical model to assist computer-based decision-making for port authorities. The approach is based on a review of the factors affecting the integration of not only ports but other nodes such as cities and regions. We also consider current computational decision-making models used to describe the dynamics of sea ports in anticipation that in the future there will be a need for integration between two or more regional sea ports which also takes into account their international role and local socio-economic responsibility.