Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/141962
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- Title
- Effect of a low glycemic index compared with conventional healthy diet on polycystic ovary syndrome
- Related
- American journal of clinical nutrition, Vol. 92, Issue 1, (2010), p.83-92
- DOI
- 10.3945/ajcn.2010.29261
- Publisher
- American Society for Nutrition
- Date
- 2010
- FoR/RFCD Code(s)
-
111100 Nutrition and Dietetics
111400 Paediatrics and Reproductive Medicine
- Author/Creator
- Marsh, Kate A
- Author/Creator
- Steinbeck, Katharine S
- Author/Creator
- Atkinson, Fiona S
- Author/Creator
- Petocz, Peter
- Author/Creator
- Brand-Miller, Jennie C
- Description
- Background: Women with polycystic ovarian syndrome (PCOS) are intrinsically insulin resistant and have a high risk of cardiovascular disease and type 2 diabetes. Weight loss improves risk factors, but the optimal diet composition is unknown. Low–glycemic index (low-GI) diets are recommended without evidence of their clinical effectiveness. Objective: We compared changes in insulin sensitivity and clinical outcomes after similar weight losses after consumption of a low-GI diet compared with a conventional healthy diet in women with PCOS. Design: We assigned overweight and obese premenopausal women with PCOS (n = 96) to consume either an ad libitum low-GI diet or a macronutrient-matched healthy diet and followed the women for 12 mo or until they achieved a 7% weight loss. We compared changes in whole-body insulin sensitivity, which we assessed using the insulin sensitivity index derived from the oral-glucose-tolerance test (ISIOGTT); glucose tolerance; body composition; plasma lipids; reproductive hormones; health-related quality of life; and menstrual cycle regularity. Results: The attrition rate was high in both groups (49%). Among completers, ISIOGTT improved more with the low-GI diet than with the conventional healthy diet (mean ± SEM: 2.2 ± 0.7 compared with 0.7 ± 0.6, respectively; P = 0.03). There was a significant diet-metformin interaction (P = 0.048), with greater improvement in ISIOGTT among women prescribed both metformin and the low-GI diet. Compared with women who consumed the conventional healthy diet, more women who consumed the low-GI diet showed improved menstrual cyclicity (95% compared with 63%, respectively; P = 0.03). Among the biochemical measures, only serum fibrinogen concentrations showed significant differences between diets (P < 0.05). Conclusion: To the best of our knowledge, this study provides the first objective evidence to justify the use of low-GI diets in the management of PCOS.
- Description
- 10 page(s)
- Subject Keyword
- 111100 Nutrition and Dietetics
- Subject Keyword
- 111400 Paediatrics and Reproductive Medicine
- Resource Type
- journal article
- Organisation
- Macquarie University. Dept. of Statistics
- Identifier
- http://hdl.handle.net/1959.14/141962
- Identifier
- ISSN:1938-3207
- Identifier
- mq-rm-2010001745
- Language
- eng
- Reviewed
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