Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/139277
38 Visitors
40 Hits
0 Downloads
- Title
- The Pathophysiology of cigarette smoking and age-related macular degeneration
- Related
- International Symposium on Retinal Degenerations (13th : 2008) (18 - 23 September 2008 : Sichuan Sheng, China)
- Related
- Anderson, Robert E.; Hollyfield, Joe G.; LaVail, Matthew M. and Mandal, Md. Nawajes A.. Retinal degenerative diseases : laboratory and therapeutic investigations, p.437-446
- DOI
- 10.1007/978-1-4419-1399-9_50
- Related
- Advances in experimental medicine and biology Vol. 664
- Publisher
- New York ; London : Springer
- Date
- 2010
- Author/Creator
- Dhubhghaill, S. S. Ni
- Author/Creator
- Cahill, M. T
- Author/Creator
- Campbell, M
- Author/Creator
- Cassidy, L
- Author/Creator
- Humphries, M. M
- Author/Creator
- Humphries, P
- Description
- Age-related macular degeneration (AMD) is the most common form of visual impairment, in people over 65, in the Western world. AMD is a multifactorial disease with genetic and environmental factors influencing disease progression. Cigarette smoking is the most significant environmental influence with an estimated increase in risk of 2- to 4-fold. Smoke-induced damage in AMD is mediated through direct oxidation, depletion of antioxidant protection, immune system activation and atherosclerotic vascular changes. Moreover, cigarette smoke induces angiogenesis promoting choroidal neovascularisation and progression to neovascular AMD. Further investigation into the effects of cigarette smoke through in vitro and in vivo experimentation will provide a greater insight into the pathogenesis of age-related macular degeneration.
- Description
- 10 page(s)
- Subject Keyword
- experimental choroidal neovascularization
- Subject Keyword
- induced oxidative damage
- Subject Keyword
- vitamin-c
- Subject Keyword
- lipid-peroxidation
- Subject Keyword
- epithelial-cells
- Subject Keyword
- 5-year incidence
- Subject Keyword
- gas-phase
- Subject Keyword
- maculopathy
- Subject Keyword
- complement
- Subject Keyword
- nicotine
- Resource Type
- conference paper
- Organisation
- Macquarie University. Dept. of Chemistry and Biomolecular Sciences
- Identifier
- http://hdl.handle.net/1959.14/139277
- Identifier
- ISBN:9781441913982
- Identifier
- ISSN:0065-2598
- Identifier
- mq_res-ext-201109230828-33
- Language
- eng
- Reviewed
