Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/134286
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- Title
- The Biological mechanisms of PCNA and BMP in TMJ adaptive remodeling
- Related
- Angle orthodontist, Vol. 81, No. 1, (2011), p.93-101
- DOI
- 10.2319/091609-522.1
- Publisher
- E H Angle Orthodontists Research & Education Foundation
- Date
- 2011
- Author/Creator
- Barnouti, Zoe Potres
- Author/Creator
- Owtad, Payam
- Author/Creator
- Shen, Gang
- Author/Creator
- Petocz, Peter
- Author/Creator
- Darendeliler, M. Ali
- Description
- Objectives: To histologically and immunohistochemically assess the pattern of expression of bone morphogenic proteins 2 and 4 (BMP2/4) and proliferating cell nuclear antigen (PCNA) in response to bite jumping appliances in the condylar cartilage and the glenoid fossa. Materials and Methods: Fifty-five 4-week-old female Sprague-Dawley rats were randomly divided into four experimental and four control groups. Bite-jumping appliances were fitted to the experimental animals. The rats were sacrificed at 3, 14, 21, and 30 days, and the temporomandibular structures were analyzed histologically and immunohistochemically. Results: The expression of BMP2/4 in response to bite-jumping appliances was statistically significant in the condylar cartilage and the glenoid fossa. Cell proliferation was not significant. Conclusion: BMP2/4 plays an important role in bone formation in response to mandibular advancement by accelerating and enhancing the differentiation of mesenchymal cells into boneforming cells.
- Description
- 9 page(s)
- Subject Keyword
- BMP2/4
- Subject Keyword
- Mandibular advancement
- Subject Keyword
- PCNA
- Subject Keyword
- Temporomandibular joint
- Resource Type
- journal article
- Organisation
- Macquarie University. Dept. of Statistics
- Identifier
- http://hdl.handle.net/1959.14/134286
- Identifier
- ISSN:0003-3219
- Identifier
- mq_res-ext-2-s2.0-78649582225
- Language
- eng
- Reviewed
