Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/130670
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- Title
- Longitudinal study of cerebral blood flow in Alzheimer's disease using photon emission tomography
- Related
- Psychiatry research. Neuroimaging, Vol. 68, Issue 2-3, (1997), p.133-141
- DOI
- 10.1016/S0925-4927(96)02792-8
- Publisher
- Elsevier
- Date
- 1997
- Author/Creator
- Sachdev, Perminder S
- Author/Creator
- Gaur, Rakesh
- Author/Creator
- Brodaty, Henry
- Author/Creator
- Walker, Alexandra J
- Author/Creator
- Meares, Susanne
- Author/Creator
- Koder, Deborah
- Author/Creator
- Haindl, Walter
- Description
- Ten patients with probable Alzheimer's disease were assessed at baseline and a mean 2 years later using a battery of neuropsychological tests, CT scans and Tc99m-HMPAO SPECT scans. The subjects had declined significantly in their functional indices. Cerebral perfusion measures declined in the parietal lobes, left hemisphere and whole brain, but the overall decline did not reach statistical significance. The decline in brain perfusion did not correlate significantly with the decline in various indices of neuropsychological function, either globally or for specific brain regions. The index of cerebral perfusion correlated significantly with global indices of neuropsychological function at baseline but not at follow-up. No single perfusion index was a significant predictor of clinical progression of dementia.
- Description
- 9 page(s)
- Subject Keyword
- Alzheimer's disease
- Subject Keyword
- SPECT
- Subject Keyword
- cerebral blood flow
- Subject Keyword
- neuropsychological function
- Resource Type
- journal article
- Organisation
- Macquarie University. Dept. of Psychology
- Identifier
- http://hdl.handle.net/1959.14/130670
- Identifier
- ISSN:1872-7506
- Identifier
- mq_res-20110708-170455
- Language
- eng
- Reviewed
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