Anticipation of onset age in familial Parkinson's disease without SCA gene mutations | Macquarie University ResearchOnline

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Title: Anticipation of onset age in familial Parkinson's disease without SCA gene mutations
Related: Parkinsonism and related disorders, Vol. 12, Issue 5 (2006), p.309-313
DOI: 10.1016/j.parkreldis.2006.01.002
Publisher: Elsevier
Date: 2006
FoR/RFCD Code(s): 110300 Clinical Sciences
Author/Creator: Huang, Yue
Author/Creator: Hayes, Michael
Author/Creator: Harding, Antony J
Author/Creator: Brooks, William S
Author/Creator: Fung, Victor S. C
Author/Creator: Rowe, Dominic
Author/Creator: Joffe, Ron
Author/Creator: Crimmins, Denis
Author/Creator: Hely, Mariese
Author/Creator: Halliday, Glenda M
Description: Assessment of a series of 279 cases with Lewy body disease revealed 14 families having a family history consistent with autosomal dominant inheritance, eight of these with dominant Parkinsonism and six with dominant dementia. Analysis of the age at onset and genetic features in these families revealed significant anticipation only in a subset of parkinsonian families, with no pathological alleles for spinocerebellar ataxias or the common α-synuclein or LRRK2 point mutations.
Description: 5 page(s)
Subject Keyword: 110300 Clinical Sciences
Subject Keyword: anticipation
Subject Keyword: autosomal dominant inheritance
Subject Keyword: dementia with Lewy bodies
Subject Keyword: Parkinson's disease
Resource Type: journal article
Organisation: Macquarie University. Australian School of Advanced Medicine

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