Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/117764
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- Title
- Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community
- Related
- Movement disorders, Vol. 24, Issue 2 (2009), p.290-292
- DOI
- 10.1002/mds.22389
- Publisher
- Wiley-Blackwell Publishing
- Date
- 2009
- FoR/RFCD Code(s)
-
110300 Clinical Sciences
110600 Human Movement and Sports Science
170200 Cognitive Sciences
- Author/Creator
- Mehta, Prachi
- Author/Creator
- Mellick, George D
- Author/Creator
- Sue, Carolyn M
- Author/Creator
- Rowe, Dominic B
- Author/Creator
- Halliday, Glenda M
- Author/Creator
- Jones, Michael M
- Author/Creator
- Manwaring, Neil
- Author/Creator
- Vandebona, Himesha
- Author/Creator
- Silburn, Peter A
- Author/Creator
- Wang, Jie Jin
- Author/Creator
- Mitchell, Paul
- Description
- MtDNA haplogroups J and K have been associated with a decreased risk of developing Parkinson's disease (PD). To confirm this finding, we compared the distribution of mtDNA haplogroups J and K in a large sample of Australian patients with PD (n = 890) to population-based controls (n = 3,491). We assigned subjects to haplogroups J or K using standard PCR/RFLP techniques. Of the 890 subjects with PD, 10.6% were haplogroup J (95% CI 8.6–12.8, n = 94) and 7.1% were haplogroup K (95% CI 5.5–8.9, n = 63). In our controls, 10.2% belonged to haplogroup J (95% CI 9.2–11.2, n = 356), and 7.8% were in haplogroup K (95% CI 6.9–8.7, n = 272). There was no significant difference in the prevalence of mtDNA haplogroup J or K in PD patients compared to population-based controls. Our findings indicate that mtDNA haplogroups J and K are not associated with a lower risk of PD.
- Description
- 3 page(s)
- Subject Keyword
- 110300 Clinical Sciences
- Subject Keyword
- 110600 Human Movement and Sports Science
- Subject Keyword
- 170200 Cognitive Sciences
- Subject Keyword
- Parkinson's disease
- Subject Keyword
- mitochondrial DNA haplogroups
- Subject Keyword
- prevalence
- Resource Type
- journal article
- Organisation
- Macquarie University. Australian School of Advanced Medicine
- Identifier
- http://hdl.handle.net/1959.14/117764
- Identifier
- ISSN:0885-3185
- Identifier
- mq-rm-2009006911
- Language
- eng
- Reviewed
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