Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/117610
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- Title
- Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?
- Related
- Movement disorders, Vol. 24, Issue 6 (2009), p.833-838
- DOI
- 10.1002/mds.22214
- Publisher
- Wiley-Blackwell Publishing
- Date
- 2009
- FoR/RFCD Code(s)
-
110300 Clinical Sciences
110600 Human Movement and Sports Science
170200 Cognitive Sciences
- Author/Creator
- Sutherland, Greg T
- Author/Creator
- Halliday, Glenda M
- Author/Creator
- Silburn, Peter A
- Author/Creator
- Mastaglia, Frank L
- Author/Creator
- Rowe, Dominic B
- Author/Creator
- Boyle, Richard S
- Author/Creator
- O'Sullivan, John D
- Author/Creator
- Ly, Tina
- Author/Creator
- Wilton, Steve D
- Author/Creator
- Mellick, George D
- Description
- Recent whole genome association studies provided little evidence that polymorphisms at the familial Parkinsonism loci influence the risk for Parkinson's disease (PD). However, these studies are not designed to detect the types of subtle effects that common variants may impose. Here, we use an alternative targeted candidate gene approach to examine common variation in 11 genes related to familial Parkinsonism. PD cases (n = 331) and unaffected control subjects (n = 296) were recruited from three specialist movement disorder clinics in Brisbane, Australia and the Australian Electoral Roll. Common genetic variables (76 SNPs and 1 STR) were assessed in all subjects and haplotype, genotype, and allele associations explored. Modest associations (uncorrected P < 0.05) were observed for common variants around SNCA, UCHL1, MAPT, and LRRK2 although none were of sufficient magnitude to survive strict statistical corrections for multiple comparisons. No associations were seen for PRKN, PINK1, GBA, ATP13A2, HTRA2, NR4A2, and DJ1. Our findings suggest that common genetic variables of selected PD-related loci contribute modestly to PD risk in Australians.
- Description
- 6 page(s)
- Subject Keyword
- 110300 Clinical Sciences
- Subject Keyword
- 110600 Human Movement and Sports Science
- Subject Keyword
- 170200 Cognitive Sciences
- Subject Keyword
- association
- Subject Keyword
- Parkinson's disease
- Subject Keyword
- PD-related genes
- Resource Type
- journal article
- Organisation
- Macquarie University. Australian School of Advanced Medicine
- Identifier
- http://hdl.handle.net/1959.14/117610
- Identifier
- ISSN:0885-3185
- Identifier
- mq-rm-2009006910
- Language
- eng
- Reviewed
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