The Influence of the relative timing of arterial and subarachnoid space pulse waves on spinal perivascular cerebrospinal fluid flow as a possible factor in syrinx development | Macquarie University ResearchOnline

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The Influence of the relative timing of arterial and subarachnoid space pulse waves on spinal perivascular cerebrospinal fluid flow as a possible factor in syrinx development

Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.14/117575

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Title: The Influence of the relative timing of arterial and subarachnoid space pulse waves on spinal perivascular cerebrospinal fluid flow as a possible factor in syrinx development
Related: Journal of neurosurgery, Vol. 112, No. 4 (2010), p.808-813
DOI: 10.3171/2009.5.JNS08945
Publisher: American Association of Neurological Surgeons
Date: 2010
FoR/RFCD Code(s): 110900 Neurosciences 110300 Clinical Sciences
Author/Creator: Bilston, Lynne E
Author/Creator: Stoodley, Marcus A
Author/Creator: Fletcher, David F
Description: Object. The mechanisms of syringomyelia have long puzzled neurosurgeons and researchers alike due to diffi-culties in identifying the driving forces behind fluid flow into a syrinx, apparently against a pressure gradient between the spinal cord and the subarachnoid space (SAS). Recently, the synchronization between CSF flow and the cardiac cycle has been postulated to affect fluid flow in the spinal cord. This study aims to determine the effect of changes in the timing of SAS pressure on perivascular flow into the spinal cord. Methods. This study uses a computational fluid dynamics model to investigate whether the relative timing of a spinal artery cardiovascular pulse wave and fluid pressure in the spinal SAS can influence CSF flow in the perivascular spaces. Results. The results show that the mass flow rate of CSF through a model periarterial space is strongly influenced by the relative timing of the arterial pulse wave and the SAS pressure. Conclusions. These findings suggest that factors that might alter the timing of the pulse wave or the fluid flow in the SAS could potentially affect fluid flow into a syrinx.
Description: 6 page(s)
Subject Keyword: 110900 Neurosciences
Subject Keyword: 110300 Clinical Sciences
Subject Keyword: cerebrospinal fluid flow
Subject Keyword: fluid dynamics
Subject Keyword: perivascular space
Subject Keyword: subarachnoid space
Resource Type: journal article
Organisation: Macquarie University. Australian School of Advanced Medicine

Identifier: http://hdl.handle.net/1959.14/117575
Identifier: ISSN:0022-3085
Identifier: mq-rm-2010003964
Language: eng
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